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Genes and Environment in Multiple Sclerosis

Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at genes, things people are exposed to, and the body's defense system that may raise the risk of multiple sclerosis (MS). It is for people in the United States who have a close family member with MS, have had certain treatments, or are being checked for new nerve-related symptoms.

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You must live in the United States and fit at least one of these groups:
  • You have a parent, sibling, or child with MS.
  • You have received anti-TNFa medicine, which reduces inflammation, for a disease other than MS, such as Crohn's disease, psoriasis, or rheumatoid arthritis.
  • You were referred to be checked for nerve-related symptoms appearing for the first time, but have not been diagnosed with MS.

Who can't join

  • You do not meet the study's entry requirements.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * First Degree Relatives of Patients with MS, or * Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or * Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS * Live in the United States Exclusion Criteria: * Does not match any of the inclusion criteria

Study sites (5)

MA

MD

  • National Institute of Neurological Disorders and Stroke · Bethesda, MD 15213Daniel S Reich, MD, PhD · Principal investigatorMore trials in Bethesda

NY

PA