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Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
21 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study uses brain scans to measure amyloid and tau, proteins in the brain linked to Alzheimer's disease. It looks at how their levels change over one year in adults with typical or less common forms of Alzheimer's disease.

This is a neuroimaging study designed to learn more about amyloid and tau burden in the brain of patients with typical and atypical Alzheimer's Disease and how burden may change over a one year period.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You must be older than 21.
  • You must have someone who can give an independent report of how you manage daily tasks.
  • English must be your main language.
  • Your symptoms must have started slowly and gotten worse. You must meet diagnosis rules for typical Alzheimer's or a less common form, such as logopenic aphasia (language problems) or posterior cortical atrophy (problems processing what you see).
  • If you have logopenic aphasia, language problems must have started early and be your main problem.
  • If you have typical Alzheimer's, your memory of personal events must be less affected than other areas of memory.

Who can't join

  • You had a stroke or tumor that could explain your symptoms.
  • You had early problems remembering personal events, or you meet diagnosis rules for mild cognitive impairment (milder memory or thinking problems).
  • You meet diagnosis rules for certain other diseases that damage the brain: behavioral variant frontotemporal dementia, semantic dementia, primary progressive apraxia of speech, probable corticobasal syndrome, or progressive supranuclear palsy.
  • You have very poor vision (20/400).
  • You are pregnant, or you have given birth and are breastfeeding.
  • You cannot have the tau-PET brain scan because an ECG heart test shows a prolonged QT interval (a delay in the heart's electrical recovery).
  • You have any of these conditions, which may raise cancer risk: Cowden disease, Lynch syndrome, hypogammaglobulinemia, Wiskott-Aldrich syndrome, or Down syndrome.
  • You cannot safely have an MRI, such as because of metal in your head or a pacemaker; have a severe fear of tight spaces; have a brain problem that could affect scans, such as bleeding or a tumor; have unstable health; or take medicines that may affect brain structure or activity, such as chemotherapy.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Over the age of 21 * Must have an informant who will be able to provide independent evaluation of functioning * English is primary language * All subjects must have insidious onset, report progression of their symptoms, and meet current clinical diagnostic criteria for typical amnestic AD or an atypical AD syndrome such as Logopenic Aphasia (LPA) or Posterior Cortical Atrophy (PCA). * All subjects with Logopenic Aphasia (LPA) must present with early and dominant impairments in language * All subjects with typical amnestic AD must have relative preservation of episodic memory compared to impairment in the non-episodic memory domain Exclusion Criteria: * If you have had a stroke or tumor that could explain your symptoms * Subjects that present with early episodic memory impairment or meet clinical criteria for mild cognitive impairment will not be recruited into the study * Subjects that meet specific criteria for another neurodegenerative disorder, including behavioral variant frontotemporal dementia, semantic dementia, primary progressive apraxia of speech, probable corticobasal syndrome, or progressive supranuclear palsy, will be excluded * Subjects will be excluded if they have poor vision (20/400) * Women that are pregnant or post-partum and breast-feeding will be excluded * Subjects will be excluded from the study if they are unable to undergo the tau-PET scan due to a prolonged QT interval on ECG, or if they have any of the following genetic conditions which can increase the chance of cancer: Cowden disease, Lynch syndrome, hypogammaglobulinemia, Wiskott-Aldrich syndrome, and Down's syndrome * Subjects will also be excluded if MRI is contraindicated (metal in head, cardiac pace maker, e.t.c.), if there is severe claustrophobia, if there are conditions that may confound brain imaging studies (e.g. structural abnormalities, including subdural hematoma or intracranial neoplasm), or if they are medically unstable or are on medications that might affect brain structure or metabolism,(e.g. chemotherapy)

Study sites (1)

MN