RightFit
RecruitingPhase not listed

Molecular Basis for Variations in Hereditary Colorectal Cancer Syndromes

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Questionnaires, Blood draws

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants: Questionnaires: If participant agrees to take part in this study, participant will fill out a some questionnaires about participant's work, family history, medical history, and health habits."
  • "If participant has already answered these questionnaires when participant was registered as a patient at MD Anderson, the study staff will give participant a copy and review participant's answers with participant for any updates or if participant has any questions."
  • "It should take about 20 minutes to complete the questionnaires."
  • "Participant will also complete a health and lifestyle questionnaire, which contains 20 questions for men and 22 questions for women."
  • "This questionnaire should take about 10 minutes to complete."
  • "If mailed, a postage-paid return envelope will be provided for the return of the questionnaire."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how gene changes passed down in families may affect colorectal cancer, which starts in the colon or rectum. It studies differences in cancer, survival, and health habits among adults who have or may have an inherited colorectal cancer condition and their family members.

Objectives: 1. To examine the variations in clinical features, survival outcomes, family history, and health behavior among proband patients who are known or suspected to have a hereditary colorectal cancer syndrome 2. To compare the clinical features, survival outcomes, and health behavior of the proband vs. his/her family members who may or may not be affected by the hereditary colorectal cancer syndrome 3. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in the overall disease phenotype across probands and kindreds, within a given syndrome. Disease phenotype is defined to include: (1) clinicopathologic features including patient demographics and oncologic outcomes; (2) clinical manifestations of disease including the timing, spectrum and severity of CRC and extracolonic cancers. Genetic variations may include the specific codon mutated, the type of mutation and sequence alteration (e.g. nonsense, missense etc), chromosomal/gene copy number changes, and gene polymorphisms. 4. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in somatic CRC tumor biology, including tumor pathology and other tumor molecular markers

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You must be at least 18 years old when you join.
  • You must understand enough English and be able to give consent to join.
  • To join as the main patient, you must have or be suspected of having an inherited colorectal cancer condition.
  • To join as a family member, you must be a close relative of an eligible main patient registered at MDACC. This includes parents, children, siblings, grandparents, grandchildren, aunts, uncles, nieces, nephews, and half-siblings.

Who can't join

    Simplified for readability. The official criteria below are what the study team uses.

    Official eligibility criteria

    Inclusion Criteria: Probands who meet the following criteria will be eligible: 1. Patient must have or is suspected to have a hereditary CRC syndrome 2. Patient must be at least 18 years of age at the time of study registration. 3. Patient must have sufficient command of the English language and mental capacity to provide consent Family members who meet the following criteria will be eligible: 1. First- or second-degree relative of a registered MDACC patient who has met eligibility criteria for a Proband as defined above. 2. Family member must be at least 18 years of age at the time of study registration. 3. Family member must have sufficient command of the English language and mental capacity to provide consent Exclusion Criteria: N/A

    Study sites (1)

    TX