RightFit
RecruitingPhase 1 / Phase 2

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation."
  • "Hyperpolarized Xenon-129 MRI has been developed by a number of techniques for imaging the lung that provide information about various aspects of lung function and structure."
  • "We will directly compare human ventilation lung images in subjects with COPD, using nuclear medicine ventilation imaging with Xenon-133 gas scintigraphy versus hyperpolarized xenon-129 gas MRI."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Subjects must have a diagnosis of COPD * at their clinical baseline on the day of imaging * must be clinically stable in order to participate in the study. * COPD subjects will be categorized according to the GOLD * Current/Former SmokerSubjects * must have a smoking history ≥ 10 pack years Exclusion Criteria: * Dx of asthma * Continuous oxygen use at home * Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging * FEV1 percent predicted less than 25% * Pregnancy or lactation * Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning * Subjects with any implanted device that cannot be verified as MRI compliant will be excluded * Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches * History of congenital cardiac disease, chronic renal failure, or cirrhosis * Inability to understand simple instructions or to hold still for approximately 10 seconds * History of respiratory infection within 2 weeks prior to the MR scan * History of MI, stroke and/or poorly controlled hypertension.

Study sites (1)

VA