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Objectively Diagnose and Monitor Treatment of Light Sensitivity

Use of Facial Feature to Objectively Diagnose and Monitor Treatment of Light Sensitivity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests a new way to measure light sensitivity and headaches and track treatment. It measures how the face, eyes, and nerves respond to light. It is for adults ages 18–80 who are healthy, have a traumatic brain injury (TBI), or have light sensitivity.

The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • All groups: You must be 18–80 years old and fit one of the groups below.
  • Healthy group: You are healthy and had a normal eye exam in the past year.
  • Brain injury group without light sensitivity or headache: You have a TBI, which is a brain injury caused by trauma.
  • Light sensitivity group without TBI: You report light sensitivity. The cause may be known or unknown.
  • Brain injury group with light sensitivity: You have a TBI and report light sensitivity caused by that injury.

Who can't join

  • All groups: You have an eye or body illness that affects the retina (the light-sensing layer of the eye), the nerve linking the eye to the brain, other vision pathways, or the pupil.
  • All groups: You have diabetes or high blood pressure that is not well controlled.
  • Healthy group and light sensitivity group without TBI: You have had head trauma, a concussion, or a TBI.
  • Healthy group and light sensitivity group without TBI: You have had a neck or spine injury or surgery.
  • Healthy group and brain injury group without light sensitivity: You are light sensitive or get migraines.
  • All groups except the TBI group with light sensitivity: You use medicines or eye drops that affect pupil or muscle-response tests. These include some eye medicines, sedatives (calming medicines), and opioid pain medicines.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Healthy Control subjects: Inclusion Criteria * Healthy individuals with normal eye exam in the previous year * Age 18-80 Exclusion Criteria * History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury/surgery * Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics * Must not be light sensitive or get migraine headaches TBI patients without photosensitivity or headache: Inclusion Criteria * Age 18-80 * Traumatic Brain Injury (TBI) Exclusion Criteria * History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled * Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics - Must not be light sensitive or get migraine headaches (use headache criteria from Ana if we are including headaches) Patients with photosensitivity from non-TBI causes Inclusion Criteria * Age 18-80 * Photosensitivity: determined by patient reporting symptoms and there may or may not be an identified cause associated with their light sensitivity (i.e. history of uveitis, childhood exotropia, meningitis, radiation, tumor) Exclusion Criteria * History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury/surgery * Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics TBI patients with photosensitivity Inclusion Criteria * Age 18-80 * Photosensitivity: determined by patient reporting symptoms and cause associated with their light sensitivity is post TBI * TBI Exclusion Criteria \- History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled

Study sites (1)

IA