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OCT Angiography and NRAI in Dementia

Using Optical Coherence Tomography and Noninvasive Retinal Amyloid Imaging to Capture Retinal Changes Associated With Dementia

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
55 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria for dementia subjects: * Physician-confirmed diagnosis of probable Alzheimer's disease * Mild dementia, as defined by score of 20 or greater on the Mini-Mental State Exam, or score of 15 or greater on the Montreal Cognitive Assessment, or Clinical Dementia Rating Scale score of 1. * Age older than 55 years. * Able to comply with study procedures * Corrected visual acuity at least 20/400 in either eye. * Has a legally authorized representative who can sign study consent form and accompany the participant to the OCT study visit. Inclusion Criteria for dementia-free controls: * Age older than 55 years * Able to comply with study procedures * Able to maintain stable fixation for OCT imaging * Corrected visual acuity of at least 20/40 in either eye * Dementia-free, as defined by score of 24 or greater on the Mini-Mental Status Exam, or a score of 18 or greater on the Montreal Cognitive Assessment, or Clinical Dementia Rating of \<1.0. Exclusion Criteria for both dementia and dementia-free subjects: * Non-Alzheimer's disease related primary neurologic disease affecting the central nervous system (i.e. multiple sclerosis, Parkinson's disease) * Evidence on ophthalmological exam within the last year of other ocular diseases or pathology that would confound the assessment of dementia (e.g. glaucoma, diabetic or hypertensive retinal disease, amblyopia, etc.) * Media opacity such as cataract, corneal scar, or vitreous opacity that could interfere with retinal imaging. * Previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber intraocular lens implantation * Inability to maintain stable fixation for OCT imaging or provide informed consent * Spherical equivalent refractive error greater than +3 or -7 diopters, or astigmatism magnitude of greater than 2 diopters. * Diabetes for more than 10 years or hemoglobin A1C level of \> 10 within the 180 days prior to OCT scanning. * Uncontrolled hypertension. : SBP \> 170 or DBP \> 100 * Arrhythmia: irregular pulse, or heart rate not between 50 and 110 beats per minute * Pregnancy or breast feeding.

Study sites (1)

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