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Sleep-dependent Learning in Aging

What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Age 18-80 yrs * Healthy sleeper * No diagnosed sleep or neurodegenerative disorder Exclusion Criteria: 1. Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation. 2. Past diagnosis neurological illness or head injury 3. Reported average sleep per night \< 5 or \> 9 hrs 4. Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing 5. Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants) 6. Daily caffeine intake of \> 4 cups (coffee, tea, colas) 7. Weekly alcohol intake of \> 10 cups 8. Pregnancy or \< 12 months post-partum 9. History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25 10. Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months). 11. Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form); 12. Score indicative of cognitive dysfunction (subtest scores \< 40) 13. Beck Depression Scale score indicative of depression (\> 19). Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for: 1. Left handed or ambidextrous 2. Claustrophobia 3. Presence of metal (thoroughly screened via questionnaire and metal detector) 4. Pregnancy

Study sites (1)

MA