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Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at brain activity linked to movement problems and other symptoms, such as memory or mood changes. It is for adults with Parkinson’s disease or essential tremor who qualify for deep brain stimulation (DBS) surgery. Researchers will take extra recordings from the brain’s surface and deeper areas during the surgery.

The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor. These movement disorders commonly have significant non-motor features, such as depression, cognitive and memory impairment, decreased attention, speech and language disturbances, and slower processing speeds. The investigators are interested in the brain activity associated with these motor and non-motor symptoms, and propose to investigate changes in brain activity while the investigators perform recordings of the surface and deep structures of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • A team of specialists has agreed that you qualify for DBS surgery, which uses electrical signals to help control symptoms.
  • You have Parkinson’s disease or essential tremor, a condition that causes shaking.
  • You are at least 18 years old.
  • You are willing to take part in the study tasks.

Who can't join

  • You cannot fully understand the study and give informed consent to join.
  • You cannot have surgery because of other health conditions or pregnancy.
  • You have not had an adequate trial of medicines or other treatments that do not involve surgery.
  • DBS surgery is not recommended for your symptoms.
  • You cannot take part in study activities.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Eligible for DBS surgery based on multi-disciplinary consensus review * Have a diagnosis of Parkinson's disease or Essential Tremor * A minimum of 18 years of age * Willingness to participate in the paradigms described in the protocol Exclusion Criteria: * Inability to provide full and informed consent * Are not surgical candidates due to co-morbid conditions or pregnancy * Have not undergone an adequate trial of conservative medical management * Have a clinical presentation for which DBS surgery is not indicated * Are not able to participate in study-related activities

Study sites (1)

AL