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Diffusion Basis Spectrum Imaging of the Prostate

Diffusion Basis Spectrum Imaging of the Prostate: A Virtual Biopsy to Accurately Diagnose Prostate Cancer

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
Male only
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests a scan called Diffusion Basis Spectrum Imaging (DBSI) to help find prostate cancer early without entering the body. It is for adults planning a prostate biopsy who either have no prostate cancer diagnosis or have prostate cancer being closely watched.

Diffusion Basis Spectrum Imaging (DBSI) represents a potential leap forward in improving prostate cancer early detection: a non-invasive and accurate imaging test for clinically significant prostate cancer.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are older than 18 and willing and able to agree to join after learning about the study.
  • You plan to have a prostate biopsy as part of your usual care. A biopsy removes a small tissue sample for testing.
  • You have no past prostate cancer diagnosis, or you have prostate cancer under active surveillance (close watching rather than treatment).
  • If you have no prostate cancer diagnosis, you may have a high PSA blood test result and either no past biopsy or a past biopsy that found no cancer.

Who can't join

  • You have a medical reason you cannot have an MRI scan.
  • You have metal implants, such as a pacemaker or an implanted device that shocks the heart to correct its rhythm.
  • You have a cochlear implant, a device that helps with hearing.
  • You fear tight spaces, and medicine cannot control that fear enough for the scan.
  • You cannot lie flat for more than 1 hour.
  • You have had surgery for prostate cancer, such as removal of the prostate or treatment to destroy cancer in one area.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Over 18 years of age and willing and able to provide informed consent. * Patients with no prior diagnosis of prostate cancer, who are planning to undergo prostate biopsy as clinical standard of care ("early detection cohort") * Including those men with: * an elevated PSA and no prior biopsy * an elevated PSA and a negative prior biopsy * Patients with a prior diagnosis of prostate cancer, who are currently managed with active surveillance, who are planning to undergo biopsy as clinical standard of care ("active surveillance cohort") Exclusion Criteria: * Patients with any clinical contraindication to MRI \*Including but not limited to: * Those with metallic implants, such as pacemakers or implantable cardioverter-defibrillators * Those with cochlear implants * Those with claustrophobia not relieved with medications (patients with claustrophobia who do not need medications for the scan or whose claustrophobia can be managed with medication, are eligible to participate) * Those who cannot lie flat for over 1 hour * Patients with prior prostate surgery for prostate cancer (e.g. radical prostatectomy, focal ablation)

Study sites (1)

MO