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Remote Monitoring in Progressive Supranuclear Palsy (PSP)

Remote Monitoring in Progressive Supranuclear Palsy, an Alzheimer's Disease Related Dementia

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 89 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 1 year
  • Procedures mentioned: Wearing a device, Pills, Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of approximately one year."
  • "The primary objective of this study is to determine the feasibility of using wearable sensors and digital health technology to remotely monitor patients with possible or probable PSP."
  • "Secondary objectives are to measure PSP progression using sensor-derived motor and tablet-derived speech and cognitive measures."
  • "In brief, approximately 85 individuals with possible or probable PSP, probable Parkinson's disease, possible or probable Multiple System Atrophy, and healthy controls, will be enrolled at 4-5 sites in the U.S. and followed for one year."
  • "During the monitoring period for PSP and MSA participants (1 year), a wearable pendant sensor (PAMSys, BioSensics) will be used to monitor falls and physical activity (step counts) of all participants during activities of daily living (ADL)."
  • "Participants will undergo more extensive testing every 3 months including the PSPRS, MoCA, quality of life questionnaires and functional rating scales which will be performed remotely (virtually)."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how wearable sensors and digital tools track falls, movement, speech, and thinking over about one year. It includes adults with progressive supranuclear palsy (PSP), Parkinson’s disease (PD), or multiple system atrophy (MSA), as well as healthy adults. Participants do guided check-ins from home each month and in-person visits about every 6 months.

This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of approximately one year. Participants will perform supervised remote assessments monthly and in-person assessments approximately every 6 months.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a doctor’s diagnosis of possible or probable PSP, probable PD or MSA, or be a healthy adult. Diagnoses must meet the study’s medical guidelines.
  • Be 18 to 89 years old.
  • Read and speak English fluently.
  • Be able to understand the study and agree to join, as judged by the study doctor.
  • Be able to follow the study’s steps, as judged by the study doctor.
  • Be able to walk 10 feet without help.
  • Have a caregiver who can help with all study tasks.

Who can't join

  • Have a brain, nerve, physical, or mental health condition that the study doctor thinks would prevent taking part.
  • Have a history of more than 5 falls per month, or need a walker to walk safely.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Clinical diagnosis of possible or probable PSP phenotype as defined by the 2017 MDS criteria, clinical diagnosis of at least probable PD as defined by the 2015 MDS criteria, or clinical diagnosis of at least probable MSA as defined by the 2022 MDS criteria, or healthy controls. * Male or female, aged 18 to 89 years, inclusive. * Fluent in reading and speaking English. * Capable of providing informed consent based on the investigator's judgment. * Able to comply with the protocol based on the investigator's judgment. * Able to walk 10 feet unassisted. * With access to a caregiver who is able to assist with all study-related procedures. Exclusion Criteria: * Any neurological, medical, or psychiatric condition that would preclude participation in study activities based on the investigator's judgment. * A history of frequent falls defined as more than 5 falls/month or requirement of a walker to ambulate safely.

Study sites (2)

MA

MD