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Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer

The Effects of Chemotherapy or Radiotherapy on Reproductive and Sexual Health of Early Onset Colorectal Cancer Patients

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 50 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how chemotherapy and radiation affect sexual health and the ability to have children in younger people with colon or rectal cancer. Researchers will track hormone levels and changes in sexual and reproductive health during cancer treatment.

The purpose of this study is to find out how cancer treatments (chemotherapy and/or radiation therapy) affect reproductive and sexual health in people with early onset colorectal cancer. The study researchers will observe and track changes in hormone levels and in sexual and reproductive health in people with early onset colorectal cancer. This information will help researchers know more about how cancer treatments affect reproductive and sexual health, including the ability to have children (fertility).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • At diagnosis, females must be ages 18–40 and not yet through menopause. Males must be ages 18–50.
  • Have colorectal adenocarcinoma, a type of colon or rectal cancer, confirmed by a tissue test.
  • Be able and willing to learn about the study and agree to take part.
  • Be eligible for treatment before or after surgery that aims to cure colon or rectal cancer.
  • Be willing and able to fill out study questionnaires.
  • For people with rectal cancer only: plan to receive chemotherapy, then chemotherapy and radiation together.

Who can't join

  • Have already received treatment for this cancer that travels through the body, such as chemotherapy.
  • Have another cancer now or have had another cancer in the past.
  • For females: have had surgery to remove an ovary or part of an ovary.
  • Are pregnant, confirmed by a pregnancy lab test, or breastfeeding.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * 18-40 years of age and premenopausal (female) or 18-50 years of age (male) at time of diagnosis * Histologic diagnosis of colorectal adenocarcinoma * Able and willing to participate in the informed consent process * Eligible for curative adjuvant or neoadjuvant therapy for colon or rectal cancer * Willing and able to complete protocol questionnaires * Rectal patients only: Individuals who will be receiving chemotherapy, followed by chemoradiotherapy (ChemoRT) Exclusion Criteria: * Prior systemic treatment for this malignancy * Active or prior secondary malignancy * History of ovarian resection (if female) * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception until the termination of gestation, confirmed by a positive hCG laboratory test.

Study sites (7)

NJ

NY