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Music Therapy for Patients With Alzheimer's Disease

Music Therapy for Autobiographical Memory and Neuropsychiatric Symptoms in Alzheimer Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 89 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Blood-oxygenation level-dependent (BOLD) in functional magnetic resonance imaging (fMRI) will also be also measured before and after the 8-week course of treatment."
  • "Brain activation patterns using functional magnetic resonance imaging (fMRI) will be compared before and after virtual music therapy sessions to understand if individualized virtual music therapy sessions can change cortical activity."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether online music therapy that helps people recall past events may improve memory, mood, and thinking. It is for people with mild memory or thinking problems or mild dementia due to Alzheimer's disease. Participants will have two 30-minute sessions each week for 8 weeks.

This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or mild dementia due to AD will receive two 30 minutes reminiscence-targeted virtual music therapy interventions per week for 8 weeks (a total of 16 sessions). Participants' (or supported by the study partner) self-reported and measurable outcomes including cognitive, anxiety, quality of life, and autobiographical memory will be assessed before and after the 8-week course of treatment. Blood-oxygenation level-dependent (BOLD) in functional magnetic resonance imaging (fMRI) will also be also measured before and after the 8-week course of treatment.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 18 to 89.
  • Have mild cognitive impairment (mild memory or thinking problems) with a MoCA thinking test score of 18–25, or early Alzheimer's disease with a score of 17–24.

Who can't join

  • Past head injury or concussion that caused you to pass out for more than 2 minutes.
  • Fear of tight spaces that prevents an MRI scan.
  • A medical device that is not safe for MRI, such as a pacemaker, implanted heart shock device, brain aneurysm clip, or inner ear implant.
  • Past work as a metal worker or certain metal objects in your body.
  • Other MRI safety concerns found through the MRI screening form.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age 18-89 * Mild Cognitive Impairment (MoCA score: 18-25) or Early AD (MoCA score: 17-24) Exclusion Criteria: * Head trauma, traumatic brain injury, or concussion with loss of consciousness for \>2 minutes * Claustrophobia incompatible with MRI scanning * Medical device incompatible with MRI scanning (e.g. cardiac pacemaker, implanted cardiac defibrillator, aneurysm brain clip, inner ear implant) * Prior history as a metal worker and/or certain metallic objects in the body * Exclusion Criteria will be carefully determined by the MRI screening form.

Study sites (1)

MD