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Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 70 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how the body processes long-term pain in people with fibromyalgia and rheumatoid arthritis. Fibromyalgia causes muscle and body pain, while rheumatoid arthritis causes swollen, painful joints. The study includes adults with these conditions and healthy volunteers.

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Ages 18 to 70.
  • People with fibromyalgia must meet the 1990 and 2011 American College of Rheumatology guidelines for that condition.
  • People with rheumatoid arthritis must meet the 2010 ACR-EULAR guidelines for that condition.
  • Healthy volunteers must not have major pain, tiredness, depression, or anxiety.

Who can't join

  • Diabetes.
  • Cancer.
  • Severe liver, kidney, heart, or blood vessel disease.
  • Pain caused by nerve damage.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Ages 18-70 * Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM * Fulfills the 2010 ACR-EULAR classification criteria for RA * Healthy volunteers: No significant pain/fatigue/depression/anxiety. Exclusion Criteria: * Diabetes * Cancer * Advanced liver, kidney or cardiovascular disease * Neuropathic pain

Study sites (1)

FL