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RecruitingPhase 2

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
55 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 10 visits
  • Procedures mentioned: Blood draws

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Ten study visits will be completed by each participant."
  • "The initial visit will include a blood draw and a baseline memory evaluation."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at whether body changes linked to mild memory problems are related to a past mild brain injury. It uses weak electrical currents to stimulate the brain and tests markers in blood. It is for adults age 55 and older with mild memory problems, with or without a past mild brain injury.

This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a current diagnosis of amnestic mild cognitive impairment, a condition that causes mild memory problems.
  • People with or without a past mild brain injury may join.
  • Be age 55 or older.
  • Speak English fluently.
  • Women and men of all races and ethnic groups may join.

Who can't join

  • Had a mild brain injury in the past year, or a moderate or severe brain injury at any time.
  • Ever had a major brain or nerve condition, such as a stroke, epilepsy (a seizure disorder), or a brain tumor.
  • Ever had a major heart or blood vessel condition, such as a heart attack or heart failure.
  • Currently have a substance use disorder, such as problems controlling alcohol or drug use.
  • Currently have a major mental health disorder, such as major depression or bipolar disorder.
  • Have vision or hearing problems that interfere with testing.
  • Have any electronic or metal implants in the skull or brain.
  • Take medicines known to change how the brain responds to the study's electrical stimulation.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Active diagnosis of amnestic mild cognitive impairment 2. Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample 3. Female and male subjects 4. All races/ethnicities 5. Age 55 years and older 6. Fluent in English Exclusion Criteria: 1. Mild traumatic brain injury within past year 2. Lifetime history of moderate or severe brain injury 3. Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor) 4. Lifetime major cardiovascular conditions (e.g., heart attack, heart failure) 5. Current substance use disorder 6. Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder) 7. Current vision or hearing impairment that interferes with testing 8. Any electronic and or metallic implants in the skull or brain 9. Current medication use known to alter HD-tDCS reactivity

Study sites (1)

TX