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Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
21 Years to 89 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how the location of deep brain stimulation (DBS) helps or worsens movement problems in people with Parkinson's disease. DBS uses implanted devices to send electrical signals to the brain. The study is for people who already have DBS implants and a 7T brain scan.

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have idiopathic Parkinson's disease, meaning its cause is unknown.
  • Have had surgery to place DBS devices in a brain area called the globus pallidus (GP) or subthalamic nucleus (STN).
  • Already have 7T brain images, taken with a high-strength MRI scanner.

Who can't join

  • Have a history of muscle, bone, or joint problems that greatly affect arm or leg movement.
  • Have another major brain or nerve disorder.
  • Have a history of dementia or problems with memory or thinking found using the UBACC or MacCAT-CR tests.
  • Have complications or harmful effects after surgery.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * diagnosis of idiopathic PD * have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN) * Existing 7T brain imagery Exclusion Criteria: * history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs * other significant neurological disorder * history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR) * post-operative complications or adverse effects

Study sites (1)

MN