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Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
65 Years to 82 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study compares a yearly stool test called FIT with colonoscopy, a test that looks inside the colon. It is for adults ages 65–82 who have had colon or rectal polyps (growths) removed and are due for follow-up testing.

This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are ages 65–82.
  • Speak English or Spanish.
  • Have had polyps in the colon or rectum.
  • Had no more than 2 polyps at your last colonoscopy, and none were advanced (higher risk).
  • Are due for a colonoscopy now or within 12 months.
  • Can give written consent to join the study.

Who can't join

  • Have had colon or rectal cancer.
  • Have a genetic condition that raises colon or rectal cancer risk, such as Lynch syndrome, FAP, or serrated polyposis syndrome.
  • Have inflammatory bowel disease, which causes swelling in the gut, such as Crohn’s disease or ulcerative colitis.
  • Had any advanced (higher-risk) polyps or 3 or more other polyps at your last colonoscopy.
  • Are unlikely to benefit from polyp checks because of serious health problems. Examples include heart disease treated in the past 6 months, heart failure that limits activities, lung disease needing home oxygen, or a stroke in the past 4 months.
  • Other examples include dementia that affects daily tasks, severe liver disease needing medicines for fluid buildup, confusion, or bleeding, severe kidney disease needing dialysis (a blood-cleaning treatment), or a new cancer diagnosis in the past year.
  • Cannot give written consent to join the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * English or Spanish speaking * Personal history of colorectal polyps * Most recent colonoscopy with ≤2 non-advanced polyps * Currently due or coming due within 12 months for colonoscopy * Able to provide written informed consent Exclusion Criteria: * Personal history of colorectal cancer * Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome) * Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease) * Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps * Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year) * Patients unable to provide written informed consent

Study sites (20)

AL

AZ

CA

CO

DC

FL

IL

IN

MI

MO

NC

NH

NY

OR

UT

VA