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Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
21 Years and older
Sex
Female only
Healthy volunteers
Not stated
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how parts of the brain work together in people with Parkinson’s disease and how this relates to problems with movement and thinking. It is for adults who plan to have deep brain stimulation (DBS) surgery, which uses electrical signals to treat Parkinson’s disease. The results may help improve DBS treatment in the future.

This study will help us better understand how the brain works in people with Parkinson's disease (PD). PD is a brain disease that gets worse over time, and affects over 10 million people world-wide. A common treatment for PD is Deep Brain Stimulation (DBS). To improve DBS therapy for PD, we need a deeper understanding of how the different parts of the brain work together in PD, and how this relates to movement and thinking problems that people with PD experience. We may be able to use the results of this study to improve DBS treatments in the future.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You have Parkinson’s disease with no known cause.
  • You plan to have DBS surgery at UMN as part of your regular care, using wires that direct electrical signals and a device that controls each signal separately.
  • You are at least 21 years old.

Who can't join

  • You have another serious brain or nerve disorder.
  • You have a history of dementia, a condition that affects memory and thinking.
  • After surgery, you have problems or side effects that make the study unsafe or affect its results, such as muscle spasms when stimulation is on.
  • You are pregnant.
  • You had radiation exposure in the past year that would be unsafe when added to the X-rays needed during surgery to place a strip that records brain signals.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Diagnosis of idiopathic PD * Surgery at UMN to implant DBS system with directional lead(s) and multiple independent current control IPG is planned as part of routine clinical care * At least 21 years old Exclusion Criteria: * Other significant neurological disorder * History of dementia * Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study * Pregnant women * Known radiation exposure within the last year that is determined to be unsafe when compounded with the expected radiation dose from intraoperative fluoroscopy to place ECoG strip

Study sites (1)

MN