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Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

Multifocal Transcranial Current Stimulation for Cognitive and Motor Dysfunction in Dementia

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
55 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether caregiver-led electrical brain stimulation (tES), given remotely without surgery, can improve memory, movement, and planning skills. It is for older adults with mild thinking and memory problems or mild dementia.

This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Participants must understand the study, agree to join, and sign a consent form.
  • Participants must be able and willing to follow all study requirements.
  • Participants and caregivers must be able to read, write, and communicate in English.
  • Caregivers must be at least 18 years old.
  • Caregivers must feel comfortable using a computer.
  • Caregivers must be willing to be the main caregiver and learn to give tES.
  • Caregivers must be available on weekdays throughout the study to give tES.

Who can't join

  • Participants cannot have a major mental health condition, such as major depression, schizophrenia, or psychosis.
  • Participants cannot have blindness or another disability that prevents them from doing study tasks.
  • Participants cannot have had a seizure in the past 2 years, take drugs that affect brain activity, or have certain implanted devices, such as a brain stimulator, medicine pump, or hearing implant.
  • Participants cannot have an active skin condition on the scalp, such as eczema.
  • Participants cannot score 18 or lower on the Montreal Cognitive Assessment (MoCA), a test of memory and thinking, at the in-person screening.
  • Caregivers cannot score 26 or lower on the MoCA at the in-person screening.
  • Participants and caregivers cannot join if the study team finds they do not understand the study. They must correctly answer questions about its purpose, risks, and their right to leave at any time.
  • Caregivers cannot have poor eyesight, severe hand arthritis, pain, a change in body shape, or another condition that prevents them from giving tES.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: Participants (Ps) * willing and capable to give informed consent for the participation in the study after it has been thoroughly explained * able and willing to comply with all study requirements * an informed consent form was signed * able to read, write, and communicate in English Caregiver/Administrators (As) * at least 18 years of age * able to read, write, and communicate in English * self-reported computer proficiency and willingness to learn how to use tES as defined by "yes" answers to the questions "Do you feel comfortable using a computer?" and "Are you willing to be the primary caregiver for a participant and learn how to administer tES?" * stated availability during weekdays throughout the study period to administer tES to the Ps Exclusion Criteria: Participants (Ps) * major psychiatric co-morbidity including major depressive disorder, schizophrenia or psychosis * blindness or other disabilities that prevent task performance * contraindications to tES, as recorded on a standardized screening questionnaire, which include a reported seizure within the past two years, use of neuroactive drugs, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, etc.) * the presence of any active dermatological condition, such as eczema, on the scalp a score of 18 or less on the Montreal Cognitive Assessment (MoCA) during the in-person screen * an inability to understand study procedures following review of the Informed Consent form * Understanding will be assessed by asking the participant to answer the following three questions: 1) What is the purpose of this study? 2) What are the risks of study involvement? 3) If you decide to participate, are you allowed to withdraw from the study at any time? Answers will be recorded by study personnel on the "Assessment of Protocol Understanding" form. Insufficient understanding will be defined by one or more incorrect answers, as determined at the discretion of the investigator Caregiver/Administrators (As) * mild cognitive impairment defined by a MoCA score ≤26 during the in-person screen * insufficient understanding of study procedures following review of the Informed Consent form * Understanding will be assessed by asking the participant to answer the following three questions: 1) What is the purpose of this study? 2) What are the risks of study involvement? 3) If you decide to participate, are you allowed to withdraw from the study at any time? Answers will be recorded by study personnel on the "Assessment of Protocol Understanding" form. Insufficient understanding will be defined by one or more incorrect answers, as determined at the discretion of the investigator. * poor eyesight, severe arthritis in the hands, pain, deformity or other condition that interferes with successful administration of tES

Study sites (1)

MA