RightFit
RecruitingPhase 4

Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: CT scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of type II Diabetes (T2DM) and atherosclerosis."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of type II Diabetes (T2DM) and atherosclerosis.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: 1. Male or female 40 years to 80 years of age at signing of informed consent 2. Type 2 DM of minimum 5 years duration with HbA1c ≥7.0% to ≤10.5% 3. Body mass index (BMI) ≥25 kilograms per meter squared (kg/m²) 4. Presence of two discrete coronary artery plaques with visual diameter stenosis \>20% on CCTA 5. At the baseline visit, participants must be on a stable (\>4 weeks) regiment of diabetes medications. 6. Patients using oral hormonal contraceptives must switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation Exclusion Criteria: 1. Have had a major cardiovascular event within the last 60 days 2. Have type 1 diabetes mellitus 3. Current use of GLP1-RA 4. Have a history of severe hypoglycemia and/or hypoglycemia unawareness within the last 6 months 5. Are currently planning treatment for diabetic retinopathy and/or macular edema 6. Have history of, or currently planning a coronary, carotid, or peripheral artery revascularization (ie - stent, bypass) 7. Have a history of pancreatitis 8. Have a history of ketoacidosis or hyperosmolar state/coma 9. Have a known clinically significant gastric emptying abnormality, have undergone or currently planning any gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery 10. Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years 11. Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) 12. Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement 13. Planned or Prior Bypass surgery 14. Contradiction for CCTA (e.g. serious allergic reaction to the contrast dye) or CCTA not meeting entry standards after two attempts during the Baseline CCTA visit as assessed by the imaging core lab. 15. Uncontrolled severe hypertension: systolic blood pressure \> 180 mmHg or diastolic BP \> 100 mm Hg prior to randomization (assessed at the screening visit) despite antihypertensive therapy 16. Heart Failure NYHA Class III or IV at the screening visit 17. Renal insufficiency (eGFR \<40 ml/min/1.73m2) as measured by the Modification of Diet in Renal Disease (MDRD) formula at the screening visit. 18. Hospitalization for major cardiovascular event including heart failure in the past 2 months

Study sites (1)

CA