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Identifying and Characterizing Preclinical MS

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans, Biopsies

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "The optional procedures include: Lumbar punctures (to obtain spinal fluid) Tonsil biopsy Fat biopsy (to obtain fat cells) Lymph node biopsy (to obtain lymph node tissues with immune cells) Traditional brain MRI Low-field (portable) brain MRI One in-person visit is required."
  • "Anyone who agrees to donate follow up biospecimens, undergo a procedure, or undergo an MRI will have additional in-person visits Optional visits for donating biospecimens, having a procedure or getting an MRI may take longer (up to 3 hours), depending on what is happening during the visit."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks for risk factors and changes in the body that may point to multiple sclerosis (MS) before symptoms start. It is for adults who have at least one risk factor for MS.

The purpose of this research study is to try and identify risk factors and biologic changes that suggest that someone may go on to develop multiple sclerosis before a person has shown any symptoms of the disease.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You must be age 18 or older.
  • You must have at least one MS risk factor, such as one of those listed below.
  • Radiologically isolated syndrome: scans show changes linked to MS, but you have no symptoms.
  • A parent, brother, sister, or child has MS.
  • Personal risk factors, such as smoking, obesity, Epstein-Barr virus infection, low vitamin D, or a score based on genes that shows MS risk.

Who can't join

  • You are pregnant.
  • You have been diagnosed with MS.
  • You have an ongoing autoimmune disease that affects the body as a whole. This means the immune system attacks the body's own tissues.
  • You are taking medicines that weaken the immune system.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age 18+ * Having one or more risk factors for multiple sclerosis, including one or more of the below: * Individuals known to have a radiologically isolated syndrome * Individuals with a family history of multiple sclerosis (first degree family member) * Individuals with personal risk factors, which are known to include smoking, obesity, Epstein Barr virus infections, Vitamin D deficiency, genetic risk score Exclusion Criteria: * Currently pregnant * Diagnosis of multiple sclerosis or any ongoing, systemic autoimmune disease * Ongoing treatment with immunosuppressive medications

Study sites (1)

CT