RightFit
RecruitingPhase 4

Immune Spatial Features of Guselkumab Cutaneous Response

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Biopsies

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Biopsy samples will be collected and undergo molecular profiling to correlate profiles with Guselkumab treatment response."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how guselkumab affects immune cells in areas of scalp psoriasis. The drug blocks IL-23, a part of the immune system. It is for people with scalp psoriasis who have a scalp severity score of 12 or higher.

This study examines the effect of IL-23 blockade with Guselkumab on the immune cells of scalp psoriasis lesions.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a Psoriasis Scalp Severity Index (PSSI) score of 12 or higher. This score measures how severe scalp psoriasis is.

Who can't join

  • Used medicines that weaken the immune system throughout the body in the past 4 weeks.
  • Are pregnant.
  • Have a very weak immune system due to a genetic condition or an infection.
  • Have tuberculosis (TB) or another active, serious infection.
  • Have active cancer that affects the body as a whole.
  • Are breastfeeding.
  • Have a condition that the study doctor thinks could make the study unsafe for you or affect the quality of the study data.
  • Are a male trying to father a child.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: possess a PSSI (psoriasis scalp severity index) of ≥12 Exclusion Criteria: 1. taking systemic immunosuppressives in the last 4 weeks 2. pregnancy 3. severe immunodeficiency (either from genetic or infectious causes). 4. tuberculosis or other active serious infection 5. active systemic malignancy. 6. breast-feeding 7. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. 8. Males who are trying to conceive \-

Study sites (1)

CA