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Magnetic Resonance Imaging in Radiotherapy for Breast Cancer

Magnetic Resonance Imaging in RadiotheRapy fOr bReast Cancer (MIRROR): A Pilot Study of MRI Simulation

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "To determine change in target volume with MRI simulation compared to Computerized tomography (CT) simulation."
  • "OUTLINE: MRI simulation will be performed once at baseline."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This small study tests whether using MRI scans to plan breast radiation treatment is practical and works well. It is for female patients with breast cancer who need radiation after surgery that keeps the breast.

This is a single-center, prospective pilot study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatment (RT) for breast cancer.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have an activity score of ECOG 2 or lower, or Karnofsky 60% or higher. These scores measure how well you can do daily tasks.
  • Be able to understand the study and willing to sign a consent form.
  • Have breast cancer confirmed by a tissue test. The cancer may have grown into nearby tissue or stayed where it began.
  • Need breast radiation after surgery that keeps the breast, as decided by your doctor.
  • Be female.
  • You may also join other treatment studies if your treating doctor allows it.

Who can't join

  • Have a condition or other reason on the MRI safety checklist that means you cannot have an MRI.
  • The breast tumor or the area where it was removed cannot be seen on CT or MRI scans used to plan radiation.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Participants with an Eastern Cooperative Oncology Group (ECOG) performance status \<=2 (or Karnofsky ≥\>=60%, see Appendix A). 2. Participants with the ability to understand and the willingness to sign a written informed consent document. 3. Participants may separately enroll on therapeutic clinical trials when they enroll on this trial. Note: All interventions on this protocol are standard of care, so enrollment on other therapeutic protocols is allowed at the discretion of the treating physician. 4. Patients must have pathologically confirmed invasive or in situ breast cancer. 5. Patients must have tumors in which adjuvant breast radiotherapy following breast conserving surgery is indicated, as determined by the treating physician. 6. Patients must be female. Note: Male patients are excluded due to the rarity of male breast cancer and difficulty in pursuing breast conserving surgery for male patients. Exclusion Criteria: 1. Participants with a contraindication to MRI per the MRI checklist. 2. Patients with breast tumor or tumor bed not visualized at CT or MRI during RT planning.

Study sites (1)

CA