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RecruitingEarly Phase 1

Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

Does Nerve Block Plus Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hours Better Than Nerve Block Alone?

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 85 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether adding dexamethasone, a steroid medicine taken by mouth, to a nerve block helps keep migraines from returning within 72 hours. It is for patients whose migraine pain improved after a nerve block, an injection that numbs nerves, in the emergency department.

For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a migraine that meets the medical guidelines called ICHD-3.
  • After a nerve block, headache pain dropped by at least 5 points or the pain score was 0 to 2.
  • The nerve block used bupivacaine 0.5%, a numbing medicine.

Who can't join

  • Have a head injury.
  • The headache may be caused by another condition, such as a stroke, a known tumor, or glaucoma (an eye disease).
  • Have a headache along with a viral illness.
  • Take steroid medicines long-term.
  • Have a known allergy to dexamethasone.
  • Cannot be reached by phone or text for follow-up.
  • Have diabetes during pregnancy or other diabetes that is not well controlled.
  • Have a known weakened immune system, which makes it harder to fight infections.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Meet ICHD-3 Migraine Headache Criteria * Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2 * Nerve block performed with bupivacaine 0.5% Exclusion Criteria: * Head trauma * Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma) * Headache in the setting of viral syndrome * Chronically on steroids * Known allergy to dexamethasone * Unable to reach the patient by phone or text for follow-up * Gestational diabetes or other uncontrolled diabetes * Known to be immunocompromised

Study sites (1)

TX