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Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction

Discovering New Targets for Hereditary and Sporadic Colorectal and Endometrial Cancer Risk Reduction

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Blood draws, Biopsies, Ultrasound

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "To collect tissue and blood samples for storage, so they can be made available to future research studies and scientist aiming to learn more about the underlying causes of gastrointestinal cancers and endometrial cancers, both in patients with hereditary cancer syndromes and in the general population, 2."
  • "These organoids will be derived from tissue biopsies of different parts of the intestinal tract, other GI organs, and endometrium in order to perform assessment of drug sensitivity and molecular biology experiments to understand the biology and carcinogenesis of the intestine."
  • "These tissue samples and blood samples were collected in the context of routine care and procedures performed at Weill-Cornell and NYPH."
  • "Biospecimen samples will also be collected in the context of SOC transvaginal ultrasound, hysteroscopy and endometrium biopsy performed at Weill Cornell or New York Presbyterian Hospital, including diagnostic testing, clinic and/or treatment visit."
  • "Blood samples will be collected at the time blood is taken for clinical care."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study collects and stores health data, tissue, and personal and family health histories for future cancer research. It is for adults getting screening or other care at NYPH or Weill Cornell Medicine. Researchers aim to find new ways to lower the risk of colorectal cancer (in the colon or rectum) and endometrial cancer (in the lining of the uterus).

The primary aim of this study is to collect and store data, tissue, and personal and family histories from patients being screened for colorectal cancer and/or endometrial cancer at NYPH and WCM for routine clinical care and to make these available for future use for molecular and mechanistic studies.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You must be 18 or older.
  • You must fit at least one of the next four groups:
  • You have an inherited cancer risk condition confirmed by genetic tests or medical findings and are having a scope exam of your digestive tract or screening of the uterus lining.
  • You are having routine screening at Weill Cornell Medicine/NYPH based on average cancer risk, using a digestive tract scope, an ultrasound through the vagina, or a scope inside the uterus.
  • You have colorectal cancer or cancer of the uterus lining and are coming to Weill Cornell Medicine/NYPH for surgery.
  • You are coming to Weill Cornell Medicine/NYPH for other care, such as tests, a clinic visit, or treatment.
  • You must be willing and able to sign a form agreeing to join the study.
  • You must be able to read and understand English, Spanish, or simplified Chinese.

Who can't join

    Simplified for readability. The official criteria below are what the study team uses.

    Official eligibility criteria

    The following eligibility criteria must be met as follows: 1. Age ≥ 18 years old. 2. One of the following must be met: 1. Diagnosis of a Hereditary Cancer Syndrome by positive genetic testing and/or clinical criteria to undergo an endoscopy procedure (esophagoduodenoscopy and/or colonoscopy/flexible sigmoidoscopy), or endometrial screening procedure (transvaginal ultrasound and/or hysteroscopy and/or endometrial biopsy), OR 2. Individuals coming to Weill-Cornell Medicine/NYPH to undergo an endoscopy procedure, transvaginal ultrasound, or hysteroscopy for average-risk (population-based) recommendation OR 3. Individuals diagnosed with colorectal cancer or endometrial cancer coming to Weill- Cornell Medicine/NYPH for surgical treatment OR 4. Individuals coming to Weill-Cornell Medicine/NYPH for care such as, but not limited to, diagnostic testing, clinic and/or treatment visit. 3. Willingness and ability to sign informed consent. 4. Ability to read/understand English, Spanish, and/or simplified Chinese.

    Study sites (1)

    NY