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A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 70 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how combining thinking and memory training with exercise affects learning and memory. It is for adults with multiple sclerosis (MS) who have mild to moderate trouble moving around and are not physically active.

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Be 18 to 70 years old.
  • Speak English as your main language.
  • Have MS confirmed by a neurologist, a doctor who treats the brain and nerves.
  • Have had no MS flare-ups and taken no steroids for at least 30 days.
  • Report mild to moderate trouble moving around on a rating scale.
  • Be physically inactive, based on an exercise questionnaire.
  • Be right-handed.

Who can't join

  • Have a history of brain or nerve disorders other than MS, or mental health disorders that are not controlled, such as major depression.
  • Have a health reason that makes exercise unsafe, based on a questionnaire.
  • Currently take medicines that may affect thinking or memory, such as steroids or benzodiazepines.
  • Be pregnant.
  • Have metal or electronic devices in your body that are not safe for an MRI scan.
  • Have severe trouble with thinking or memory, based on a test.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Be within the ages of 18 and 70 years of age * Speak English as their primary language * Confirmed MS diagnosis by a neurologist * Be relapse and steroid-free for at least 30 days * Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS) * Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ) * Right handedness Exclusion Criteria: * History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression) * Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q) * Currently use medications that may impact cognition (ex: steroids, benzodiazepines) * Currently pregnant * Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe) * Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)

Study sites (1)

NJ