Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma
Nasal Endotoxin Challenge to Study Mucosal Inflammation in Patients With Asthma
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Official eligibility criteria
Inclusion Criteria: * Participants will have asthma diagnosed by a health care provider. Healthy controls are individuals without asthma. * Written informed consent Exclusion Criteria: * Current or recent illness (in the past 4 weeks) * Recent asthma exacerbation (past 4 weeks) * History of nasal perforation or nasal surgery * Nasal polyposis * Presence or prior history of cardiac or systemic disease * Bleeding disorder, use of systemic anticoagulants, or antiplatelet therapy * Immunocompromised state (HIV, immunoglobulin deficiency, systemic immunosuppressants excluding corticosteroids) * Use of tobacco or marijuana in the past 2 months or greater than a 10 pack-year smoking history * Currently pregnant or breastfeeding
Study sites (1)
CO
- National Jewish Health · Denver, CO 80206William J Janssen, MD · Study contact · 303-398-1366Olivia M VerBurg, BA · Study contact · 303-398-1201William J Janssen, MD · Principal investigatorMore trials in Denver