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A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)

Cognitive Aging in Older Long-term Breast Cancer Survivors

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
60 Years to 80 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how memory, attention, and thinking change over time in breast cancer survivors. It compares women ages 60–80 who survived breast cancer with women of the same age who have not had cancer.

The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers). Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so the researchers can compare the results of neurocognitive testing (which looks at memory, attention, and information processing) on each group of participants.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Identify as female and be 60–80 years old.
  • Have access to a computer and the internet.
  • Score below 11 on the BOMC, a test of memory, attention, and awareness.
  • If taking medicines that affect mood or thinking, have no dose changes for at least 2 months before joining.
  • Speak English well or very well, understand study discussions, and prefer English for health care.
  • Breast cancer survivors: Had stage 0–3 breast cancer diagnosed at ages 50–60.
  • Breast cancer survivors: Have no signs of cancer now.
  • Comparison volunteers: Have no history of breast cancer.

Who can't join

  • Have a brain or nerve disorder that affects thinking, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, dementia, or a seizure disorder.
  • Had a stroke or head injury that caused brain damage seen on a scan, lasting thinking problems affecting daily life or work, or a need for thinking-skills therapy.
  • Have certain mental health conditions, including schizophrenia or related disorders, substance use disorder, bipolar disorder, or schizotypal personality disorder.
  • Have vision or hearing problems that prevent completing the tests.
  • Use methotrexate or rituximab for rheumatoid arthritis, psoriasis, or Crohn's disease, or cyclophosphamide for lupus.
  • Are in another research study with overlapping tests of thinking skills.
  • Breast cancer survivors: Had cancer return, a second breast cancer, or another cancer other than nonmelanoma skin cancer; or had breast cancer treated only with surgery.
  • Comparison volunteers: Had any cancer except nonmelanoma skin cancer, or received radiation, chemotherapy, tamoxifen, or aromatase inhibitors.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: All Participants: * Per medical record and/or self-report, identifies as female * Per medical record and/or self-report, currently age 60-80 * Per self-report, has access to a computer and internet connectivity * Score of \<11 on Blessed Orientation-Memory-Concentration Test (BOMC) * As per medical record or self-report, if currently taking psychoactive medications (including but not limited to antidepressants and anxiolytics), dose must have been stable at least two months prior to enrollment. * English fluent (as per self-report, fluency of "well" or "very well", and having a reasonable comprehension of the study conversation in the opinion of the research staff)\*\* Breast Cancer Survivors: * Per medical record and/or self-report, history of stage 0-3 breast cancer diagnosed between 50-60 years of age * Per medical record and/or self-report, no evidence of disease (NED) Non-Cancer Controls: * Per self-report, no history of breast cancer * Language verification: For both survivors and controls, prior to enrollment, all will be asked the following two questions by a CRC to verify English fluency necessary for participation in the study: 1. How well do you speak English? (must respond "Well" or "Very well" when given the choices of Very well, Well, Not well, Not at all, Don't know, or Refused) 2. What is your preferred language for healthcare? (must respond English) Exclusion Criteria: All participants: * As per medical record or self-report, diagnosis of neurodegenerative disorder that affects cognitive function (e.g. Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Dementia, Seizure Disorders, etc.) * As per medical record or self-report, history of stroke or head injury resulting in a structural lesion on neuropsych imaging, persistent cognitive difficulties impacting work or daily life, or required cognitive rehabilitation * As per medical record or self-report, a diagnosis of a major Axis I psychiatric disorder including Schizophrenia Spectrum Disorder, substance use disorder, Bipolar Disorder or Schizotypal personality disorder. Schizophrenia Spectrum Disorders include Schizophrenia, Schizophreniform disorder, Schizoaffective disorder, Delusional disorder, Brief psychotic disorder, and Attenuated Psychotic Disorder. * As per medical record or self-report, visual or auditory impairment that would preclude ability to complete the assessments (e.g. history of significant macular degeneration or being unable to correct hearing with hearing aids) * As per medical record or self-report, use of methotrexate (Amethopterin, Rhematrex, Trexall) or rituximab (Rituxin) for rheumatoid arthritis, psoriasis or Crohn's disease, or cyclophosphamide (Cytoxan, Neosar) for lupus. * As per medical record or self-report, participation in a conflicting (overlapping neurocognitive assessments) research study (i.e. MSK 18-294) Breast Cancer Survivors: * As per medical record or self-report, history of cancer recurrence * As per medical record or self-report, any history of another cancer except nonmelanoma skin cancer or first breast cancer (a secondary breast cancer is exclusionary) * As per medical record or self-report, breast cancer only treated with surgery Non-Cancer Controls: * As per medical record or self-report, history of treatment using radiation, chemotherapy, and/or Tamoxifen or Aromatase-inhibitors * As per medical record or self-report, any history of cancer except non-melanoma skin cancer

Study sites (7)

NJ

NY