Early Detection of Advanced Adenomas and Colorectal Cancer
A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
- Procedures mentioned: Biopsies, Blood draws
Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.
Show the study's own words
- "This study proposes developing an innovative liquid biopsy test tailored for AAs and CRC to address this."
- "This test would optimize patient compliance and resource allocation by detecting both conditions from a single blood draw."
- "This study will develop a non-invasive blood test for AA and CRC in four phases: 1."
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study aims to develop an accurate, low-cost blood test to find colon and rectal cancer and adenomas early. Adenomas are growths that may turn into cancer. The study is for people who have had a colonoscopy when their blood is collected.
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Have had a colonoscopy when blood is collected. This test uses a camera to look inside the colon and rectum.
- Have had the usual tests required by local guidelines to diagnose the condition and, if needed, check how far it has spread.
- Have at least one sample collected before any treatment meant to cure the condition.
- Have had standard tissue checks and camera exams to confirm the diagnosis and decide which study group to join.
Who can't join
- Have an inherited condition linked to colon or rectal cancer, confirmed by genetic testing.
- Have inflammatory bowel disease, which causes ongoing swelling in the gut.
- Have not given written consent to take part.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * All individuals included in the study need to have had a colonoscopy at the time of blood sampling. * Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment. * Received standard pathological and endoscopic diagnosis and assessment for cohort assignment. Exclusion Criteria: * Hereditary colorectal cancer syndromes (identified through genetic testing). * Inflammatory bowel diseases. * Lack of written informed consent.
Study sites (2)
CA
- City of Hope Medical Center · Monrovia, CA 91016Ajay Goel, PhD · Study contact · 626-218-3452 · AJGOEL@COH.ORGAjay Goel, PhD · Principal investigatorCaiming Xu · Sub-investigatorAlessandro Mannucci · Sub-investigatorMore trials in Monrovia
- University of California San Diego · San Diego, CA 92093C Richard Boland, MD, PhD · Study contactC Richard Boland, MD, PhD · Sub-investigatorMore trials in San Diego