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The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia

The Effects of Auditory Stimulation During Sleep on Offline Learning and Thalamocortical-hippocampal Connectivity in Schizophrenia

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 45 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband."
  • "On the final day of the study, participants will return for a second MRI scan."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * 18-45 years old * Fluent in English * Able to give informed consent Additional inclusion for Adults with schizophrenia: * A DSM-V confirmed diagnosis of schizophrenia * Unmedicated or maintained on a stable dose of APDs Exclusion Criteria: * Ferrous metal in the body * Currently pregnant or breastfeeding * Motor problems that preclude finger tapping task * IQ \<85 * Other neurological disorders, including seizure disorder * Significant hearing or vision loss * Chronic medical conditions that affect sleep * Unstable chronic medical condition such as asthma, diabetes, cystic fibrosis, or cardiac disease * Diagnosed sleep disorder, except insomnia * History of head injury resulting in prolonged loss of consciousness or other neurological sequelae Additional Exclusion Criteria for Healthy adults: * History of mental illness * Current use of psychotropic medications or treatment with medications known to affect sleep or cognition

Study sites (1)

MA