Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 50 Years to 90 Years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study looks at how mild cognitive impairment (MCI) and Alzheimer's disease affect walking and the ability to adjust walking movements. It is for older adults with these conditions.
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor impairments. It is also an important therapeutic target for exercise-based interventions to improve walking function. The overall goal of this study is to understand the effects of MCI and AD on locomotor adaptation and walking function.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Have MCI or Alzheimer's disease diagnosed by a board-certified brain and nerve doctor.
- For MCI, have memory concerns reported by you or your partner, plus memory test results that meet study rules.
- For MCI, score 20–26 on the Mini-Mental State Exam, a thinking and memory test. Exceptions may apply if you had less than 8 years of schooling.
- For MCI, have a Clinical Dementia Rating of 0.5, with a memory score of at least 0.5, and still manage daily activities well enough.
- Score 13–17 on the Montreal Cognitive Assessment, showing problems with thinking skills such as planning.
- Be able to walk at least 10 feet without a walking aid.
- Have finished at least sixth grade or have enough work history to rule out an intellectual disability.
- Have had no hospital stay in the past 60 days.
Who can't join
- Have a current illness that needs hospital care, or heart failure that is not controlled.
- Have ever had a stroke.
- Cannot complete study tasks, or have a condition that prevents safe participation or walking, such as severe arthritis, uncontrolled blood pressure or diabetes, kidney failure, or chest pain with activity.
- Take medicines that may harm thinking, such as antipsychotics, opioids, stimulants, chemotherapy, or certain medicines for Parkinson's disease or multiple sclerosis.
- Have a psychotic disorder, which can affect your sense of what is real.
- Have another brain or nerve condition that could affect study results, such as a brain or spinal cord infection, seizures, a brain tumor, or a head injury that caused more than 30 minutes of unconsciousness.
- Have had a substance use disorder, major depression, or generalized anxiety disorder within 6 months of the evaluation.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * AD and MCI will be defined through formal diagnosis provided by a board-certified Neurologist. Amnestic MCI will be defined using the AD Neuroimaging Initiative (ADNI) criteria. All MCI participants in ADNI are required to have an amnestic subtype defined as: * Subjective memory concern or a memory problem noted by their partner * Abnormal memory function documented by a specified education adjusted cutoff score on the delayed paragraph recall of the Anna Thompson story of the Logical Memory subtest from the Wechsler Memory Scale-Revised * Mini-Mental State Exam (MMSE) score between 20 and 26 (inclusive). Exceptions may be made for subjects with less than 8 years of education at the discretion of the PI. (iv) Single or multi-domain amnestic MCI (both subtypes are at high risk for progression to AD) * Clinical Dementia Rating (CDR) = 0.5 (Memory Box score must be at least 0.5) * General functional performance sufficiently preserved * Evidence of impaired executive function based on Montreal Cognitive Assessment (MoCA) score 13-17 * Able to walk 10 or more feet without an assistive device * Completed six grades of education or has a good work history (sufficient to exclude intellectual disabilities) * Not hospitalized within the last 60 days Exclusion Criteria: * Acute medical illness requiring hospitalization * Uncontrolled congestive heart failure * History of stroke * Inability to perform study procedures * Medical or physical conditions that would preclude participation or walking (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity) * On medications that could adversely affect cognition, eg: antipsychotics, opioids, stimulants, chemotherapy, anti-parkinsonian drugs (eg Levodopa), neurologic prescriptions to treat Multiple sclerosis and/or Parkinson's * Psychotic disorders * Confounding neurologic conditions (e.g., active central nervous system (CNS) opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae) * Substance Use Disorder, Major Depressive and Generalized Anxiety Disorders within six months of evaluation
Study sites (1)
GA
- Emory Rehabilitation Hospital · Atlanta, GA 30322More trials in Atlanta