Action Regulation Behavioral
Revealing the Action Regulation Mechanisms in the Human Brain
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years to 80 Years
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. Given that the decline of muscle control such as tremors, with difficulty walking or the ability to switch tasks once in movement, greatly affects the quality of daily life. Action regulation is a critical executive function (cognitive control over behavior), which includes actions such as suppressing activity when selecting between options, making decisions about stopping unwanted or inappropriate actions, and switching to new actions in response to environmental changes. Parkinson's disease (PD) has been shown to disrupt action inhibition which can be considered a measure to the progression of PD. The purpose of this research study is to better understand the mechanism of action regulations in PD patients and how action regulations in PD can be improved using dopaminergic treatment, which is a drug that either releases or involves dopamine, which is a neurotransmitter involved in sending signals to nerve cells. You are asked to participate in this research study because you are receiving a dopaminergic medication for treatment of your Parkinson's disease. There is currently no theory that integrates the mechanisms of action regulation into a unified framework, which this study aims to address. The researchers hope to learn more about the mechanisms of action regulation in PD patients and to help decrease action regulation disruptions in PD patients. This study will help characterize the motor behavior of PD patients.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Official eligibility criteria
For Parkinson's Disease Patients: Inclusion Criteria: * Diagnosis of Parkinson's Disease by a movement disorder neurologist * Levodopa responsive with clearly defined "on" periods, with at least 30% improvement in UPDRS III scores on vs off * Willingness and ability to complete the behavioral experiments for up 3.5 hours * No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators Exclusion Criteria: * Patients with history of secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's Disease * Patients with a disease or condition that prevents understanding or communication of informed consent, study demands, and testing protocol including cognitive decline, diagnosed forms of dementia, significant memory impairment (MoCA\<23), or hearing loss that prevents adequate communication with researcher For Healthy subjects: Inclusion Criteria: * No history any diagnosed neurological disease(s), including movement disorders or cognitive decline * No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators
Study sites (1)
TX
- University of Texas Southwestern Medical Center · Dallas, TX 75390Sahil Chilukuri · Study contact · sahil.chilukuri@utsouthwestern.eduNader Pouratian · Study contact · nader.pouratian@utsouthwestern.eduMore trials in Dallas