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Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

Hematopoiesis in Monoclonal B Cell Lymphocytosis (MBL) and B-Chronic Lymphocytic Leukemia (CLL) Versus Healthy Age-Matched Control Subjects

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Blood draws, Biopsies

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how bone marrow makes blood cells and responds to infections in people with MBL or CLL. MBL means having extra abnormal white blood cells, and CLL is a type of blood cancer. The study includes people with these conditions and healthy people for comparison.

This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • People with CLL confirmed by flow cytometry, a test that checks cells in the blood.
  • People with CLL may be untreated, getting treatment now, or have had treatment before.
  • People with a confirmed diagnosis of MBL.
  • Healthy people about the same age as those with MBL or CLL.
  • Healthy people who are younger than the other groups but over age 40.

Who can't join

  • Anyone under age 40.
  • People with CLL or MBL cannot join the healthy comparison groups.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who * Remain untreated * Are currently being treated * Who have already been treated * Subjects in the MBL cohort will have a clinically established diagnosis of MBL * Healthy age-matched control subjects * Healthy younger control subjects aged \> 40 years Exclusion Criteria: * Anyone under 40 * Healthy control subjects must not have a diagnosis of CLL or MBL

Study sites (1)

MN