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White Matter Plasticity in Schizophrenia

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
15 Years to 45 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at whether training on a pretend musical instrument can change white matter in the brain. White matter helps parts of the brain send messages quickly. The study is for people ages 15–45 with schizophrenia or related disorders.

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis not otherwise specified (NOS). These are disorders that can affect how you think and what seems real.
  • Be 15–45 years old.
  • Be able to understand the study and agree to take part.

Who can't join

  • Cannot have an MRI brain scan because of metal implants or fear of tight spaces.
  • Have a health problem, such as arthritis, that limits hand use.
  • Have a substance use disorder now or have had one in the past 6 months, except for nicotine.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS * age 15-45 * able to provide informed consent Exclusion Criteria: * contraindications to MRI (metal implants, claustrophobia) * medical condition that limits use of hands (ie, arthritis) * Active or recent (within 6 months) substance use disorder other than nicotine

Study sites (2)

MD