RightFit
RecruitingNot applicable

Neocortical Microarchitecture of Executive Function

Neocortical Microarchitecture of Executive Function Using Large-scale Intracranial Electrophysiology

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
45 Years to 85 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: 1. Diagnosis of Parkinson's disease and refractory to medications requiring deep brain stimulation 2. Aged 45-85 3. Able to provide informed consent 4. Normal neuropsychiatric evaluation that includes tests of executive function demonstrating no greater than mild impairments, within expectation for Parkinson's disease. 5. Medically able to undergo deep brain stimulation surgery as evaluated by study neurosurgeon. 6. Surgical plan includes an entry point that can safely be placed in the dorsal lateral PFC. 7. Able to tolerate awake deep brain stimulation surgery with a plan for the case to be done awake. 8. Able to tolerate 25 additional minutes of awake surgery. 9. Able to participate and comply with tasks adequately, including instructions provided in English. Exclusion Criteria: 1. Moderate, or severe cognitive impairment as determined by a licensed neuropsychologist during routine neuropsychological evaluation. 2. Inability to tolerate awake surgery as determined by the treating neurologist and study neurosurgeon. 3. Inability to safely access the dorsal lateral prefrontal cortex for an entry location. 4. Moderate or severe cognitive impairment or executive function deficits as determined by neuropsychological testing. 5. Evidence of a clinically significant abnormality on preoperative imaging.

Study sites (1)

CO