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Endometriosis and Migraine

Mechanisms Underlying Endometriosis and Migraine Comorbidity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
12 Years to 45 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 3 visits
  • Time periods mentioned: 1 year
  • Procedures mentioned: Questionnaires, Phone or video check-ins, Interviews

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses."
  • "The consent will be signed electronically using Docusign e-consent process either remotely during a phone call or a video call (WUSTL Zoom) with a study staff or in person."
  • "After confirming the inclusion criteria and signing the consent form, participants will complete a 2.5-3 hour study visit of psychophysical assessments of thermal and pressure stimuli."
  • "Participants will also complete various questionnaires including demographic, social, health, behavioral, and psychological questionnaires."
  • "For adolescents, a parent/legal guardian will be asked to assist in completing some of the health-related surveys (i.e., physical developmental survey, health survey, migraine history survey)."
  • "Obstetric, gynecologic, fertility, surgical history, medications, and pain will be abstracted from the medical record and/or via health history interview."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study compares pain responses and sex hormone levels in people with migraine, endometriosis, both conditions, or neither condition. It is for people ages 12–45 who were assigned female at birth. Participants will answer surveys, take part in pain tests, and give samples to measure hormones.

This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 12–45.
  • Assigned female at birth.
  • Have diagnosed migraine, endometriosis (tissue like the lining of the womb growing outside it), or both; or be healthy with no history of long-term pain.

Who can't join

  • Pregnant or breastfeeding.
  • Have a prolactinoma, a tumor that makes a hormone called prolactin.
  • Have a mental health, brain or nerve, hormone, or developmental condition and take medicine for it.
  • Currently take dopamine agonists or SSRIs, two types of medicine that affect brain chemicals.
  • If age 12–17, do not have a parent or legal guardian willing to sign the consent form and answer surveys about your health.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine 2. Healthy control subjects with no history of chronic pain 3. Age 12-45 4. Assigned female sex at birth Exclusion Criteria: 1. Pregnancy or breastfeeding 2. Presence of prolactinoma 3. Presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions 4. Current use of dopamine agonist or SSRI medications 5. For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health

Study sites (1)

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