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Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

Evaluating the Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines in the Emergency Department

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether adding magnesium to prochlorperazine helps reduce migraine pain. It is for adults who have been diagnosed with migraines and have headaches with typical migraine signs.

The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18 or older.
  • You can understand the study and agree to take part.
  • You speak English.
  • You have a past migraine diagnosis and headaches with at least 2–3 typical signs, such as repeated headaches, pain on one side, pounding or throbbing pain, or nausea (feeling sick to your stomach). A clinician must rule out other problems that look like migraines.

Who can't join

  • You have a positive urine pregnancy test.
  • You have an allergy or sensitivity to a study drug.
  • You report a history of kidneys that do not work well.
  • Your medical record shows myasthenia gravis, a disease that causes muscle weakness.
  • You took a study drug in the 48 hours before joining.
  • You already joined this study during an earlier visit.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age ≥ 18 years or older * Able to provide informed consent * English speaking * Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical exclusion of migraine mimics Exclusion Criteria: * Pregnancy defined as a positive urine HCG * Allergy or sensitivity to study drug * Stated history of renal insufficiency * Documented history of myasthenia gravis * Consumption of study drug within 48 hours prior to enrollment * Previously enrolled in this trial during a different patient encounter

Study sites (1)

IL