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Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how people with Parkinson's disease adjust their walking and have episodes when their feet seem stuck. Participants walk on a treadmill with two belts that move at the same or different speeds, while off medicine and with deep brain stimulation (DBS) turned on and off. It is for adults with Parkinson's disease who have had stable DBS for at least 6 months.

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are 18 to 80 years old.
  • Have Parkinson's disease with no known cause, confirmed by specialist doctors at the Normal Fixel Institute of Neurological Diseases.
  • Have had deep brain stimulation (DBS) for at least 6 months, with stable settings adjusted for your needs. DBS uses electrical signals in the brain.
  • Do not have dementia related to Parkinson's disease, based on clinical criteria. Dementia affects memory and thinking.
  • Can walk without walking aids or help from another person.

Who can't join

  • Have had other surgery on the brain or nervous system.
  • May have another nervous system condition, such as an unusual form of parkinsonism or Alzheimer's disease.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases; * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings; * Age between 18 - 80 years old per the FDA data sheet for PD DBS; * no dementia according to the clinical diagnostic criteria for PD dementia; * ambulatory without the use of walking aids, or another person's assistance. Exclusion Criteria: * other previous neurological surgery; * suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

Study sites (1)

FL