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Motor Learning of Fall Resistant Skills Through Slip and Trip Exposure in Multiple Sclerosis

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
45 Years to 89 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether people with multiple sclerosis (MS) can learn skills to resist falls through repeated slips and trips during training. It is for adults age 45 or older with MS who can walk and stand on their own.

The primary purpose of this interventional study is to examine the overall motor learning capacity from exposure to repeated perturbations among ambulatory people with multiple sclerosis (MS). This project will advance our understanding of learning new motor skills from exposure to external perturbations. If it is proven that people with MS can learn motor skills from perturbation training, the findings from this study will pave a theoretical foundation for applying perturbation training as a promising fall prevention intervention for people with MS.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have MS confirmed by a medical professional.
  • Be at least 45 years old.
  • Be able to walk at least 25 feet on your own.
  • Be able to stand for at least 30 seconds on your own.
  • Have a Patient Determined Disability Steps score of 0 to 4, a rating of how MS affects movement.
  • Not be pregnant.
  • Score at least 23 on the Montreal Cognitive Assessment, a test of thinking and memory.

Who can't join

  • Have done training with sudden balance disruptions before.
  • Have a T-score below -2.5 on a DXA scan, an X-ray test that measures bone strength.
  • Have a mental health disorder, another brain or nerve condition, a severe illness, or heart or blood vessel disease.
  • Have had an MS relapse, or flare-up, in the past 8 weeks.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Clinically confirmed multiple sclerosis 2. At least 45 years old 3. Able to walk independently at least 25 feet 4. Able to stand independently for at least 30 seconds 5. Patient Determined Disability Steps score between 0 and 4 6. Free from pregnancy 7. Montreal Cognitive Assessment score of 23 or higher Exclusion Criteria: 1. Previous experience with perturbation training 2. T-score from the dual x-ray absorptiometry (DXA) scan of less than -2.5 3. Coexisting psychiatric disorders or other neurological conditions, severe medical illness, or cardiovascular diseases 4. Participants have had a relapse in the past 8 weeks

Study sites (1)

GA