RightFit
RecruitingPhase 2

Using Xe MRI to Guide Radiation Therapy for Lung Cancer

Image-Based Functionally Adapted Radiation Therapy for Lung Cancer

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment."
  • "The rationale for the proposed research is that the implementation of functional imaging context into RT treatment planning is currently inhibited by a lack of access to routine MRI-guidance and a robust workflow to practically incorporate functional information into clinical treatment planning."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study explores MRI scans with xenon to show how well the lungs work and how this changes after radiation treatment. It also looks at using these scans to help aim radiation away from lung areas that work well. It is for adults ages 18–80 with lung cancer who plan to get stereotactic body radiation therapy, which aims radiation precisely at the cancer.

The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18–80 years old.
  • You can and will give informed consent before any study tests and follow the study visit schedule and rules.
  • A board-certified cancer doctor has diagnosed you with lung cancer and plans to treat it with stereotactic body radiation therapy.

Who can't join

  • You are under 18, are in prison or jail, are pregnant, or are breastfeeding.
  • Your MRI safety screening shows that you cannot safely have an MRI, or you do not fit in the special xenon MRI vest.
  • Your oxygen level at rest is below 90% while using extra oxygen, or you have had a bacterial or viral breathing illness within 30 days before planned treatment.
  • You have ever had an abnormal heart rhythm in the heart's lower chambers, or your heart stopped beating within the past year.
  • You have had radiation treatment to the lung before.
  • You are getting cancer medicines that raise the risk of lung swelling from radiation, such as some immune treatments or chemotherapy.
  • You cannot hold your breath for 15 seconds, or the study team thinks you may not be able to follow instructions during scans.
  • The study doctor thinks a medical or mental health condition could make participation too risky or keep you from following study rules.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial 1. Aged 18-80 years 2. Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.) 3. Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria Exclusion Criteria: Subjects presenting with any of the following will not be included in the trial: 1. Subject is less than 18 years old or incarcerated 2. MRI is contraindicated based on responses to MRI screening questionnaire 3. Subject is pregnant or lactating 4. Resting oxygen saturation \<90% on supplemental oxygen 5. Respiratory illness of bacterial or viral etiology within 30 days of planned treatment 6. Subject has history of any known ventricular cardiac arrhythmia 7. Subject has history of cardiac arrest within the last year 8. Subject has prior history of cancer treatment with radiation therapy to the lung 9. Subject has concurrent cancer treatment with agents associated with increased risk of radiation pneumonitis (e.g. immunotherapy, chemotherapy) 10. Subject does not fit into 129Xe vest coil used for MRI 11. Subject cannot hold his/her breath for 15 seconds 12. Subject deemed unlikely to be able to comply with instructions during imaging 13. Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements

Study sites (1)

IA