Imaging Core Aim 2, and Udall Project 2 Aim 2
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 21 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study looks at how brain networks work during deep brain stimulation (DBS), a treatment that uses electrical signals in the brain. The goal is to help adjust DBS settings to improve treatment and reduce side effects. It is for adults with Parkinson’s disease who have a Medtronic Percept or Percept RC DBS device that is safe for MRI scans.
More than one million people in the United States have Parkinson's disease (PD) and the prevalence is expected to double by 2040. Over 60% of these individuals will develop debilitating postural instability and gait disturbances (PIGD), including freezing of gait (FOG). With disease progression, axial motor symptoms typically become resistant to dopamine replacement therapies (e.g. levodopa) and a primary source of disability and morbidity. While subthalamic (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) using standard locations and stimulation parameters can be highly effective for the treatment of the cardinalmotorsymptomsof PD, both treatments often fail to control levodopa-resistant motor features of PD such as PIGD. DBS can also impair cognitive function which further exacerbates PIGD, particularly when the task requires attentional resources. Thus, despite considerable improvements in appendicular bradykinesia, rigidity and tremor with conventional DBS, the disease can continue to be dominated by PIGD, leading to increased falls, decreased mobility, and increased rate of hospitalization and morbidity. This is why one of the top NINDS priorities for clinical research in PD is the development of novel therapeutic approaches, such as DBS targeting, to treat levodopa-resistant motor symptoms. This study will provide crucial information to elucidate the functional properties of the networks involved in Deep Brain Stimulation (DBS) treatment. By refining our understanding of the neural networks involved in stimulation of DBS targets, we will improve our ability to program patients to enhance their clinical outcomes and minimize side effects.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Age 21 or older.
- Have a Medtronic Percept or Percept RC DBS device implanted to treat Parkinson’s disease that is safe for MRI scans.
- Speak English.
Who can't join
- Cannot give consent for yourself to join the study.
- Have a DBS device that is not safe for MRI scans.
- Are pregnant.
- Have an extreme fear of small or closed spaces.
- Have any other reason that makes an MRI scan unsafe for you.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Age 21 and up * Implanted with MR-compatible DBS device (Medtronic Percept/Percept RC DBS System) for treatment of Parkinson's disease * English speaking Exclusion Criteria: * Unable to consent for themselves * Implanted with a DBS device that is not MR compatible * Pregnant * Extreme claustrophobia * Any contraindications for MRI
Study sites (1)
MN
- University of Minnesota · Minneapolis, MN 55414Sarah Bedell · Study contact · sbedell@umn.eduMore trials in Minneapolis