RightFit
RecruitingPhase 1

Exploring the Utility of [18F]3F4AP for Demyelination Imaging

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 90 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how [18F]3F4AP, a substance used for imaging, moves through the body. It is for healthy adults and adults with conditions such as mild memory and thinking problems, Alzheimer's disease, multiple sclerosis, spinal cord injury, or pinched nerves near the spine. The goal is to explore imaging of damage to the protective covering around nerves.

The overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Be age 18 to 89.
  • Be able to understand the study and agree to take part before any study procedures.
  • Be in good health.

Who can't join

  • Be younger than 18.
  • Be pregnant or breastfeeding.
  • Have a serious illness affecting the body or a medical condition that is not stable.
  • Have an existing medical condition or a fear of enclosed spaces.
  • Have research-related radiation exposure above the PET Center's limit of 50 mSv, a measure of radiation dose, in the past 12 months.
  • Have a history of a bleeding disorder or currently take blood thinners.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion: 1. Male and Female subjects must be ≥18 and \<90 years of age; 2. Able to understand and provide informed consent prior to study procedures 3. Must be in good health Exclusion: 1. Less than 18 years of age; 2. Pregnant or breastfeeding; 3. Any significant systemic illness or unstable medical condition; 4. Pre-existing medical conditions or claustrophobic reactions; 5. Research-related radiation exposure exceeds current PET Center guidelines (i.e. 50 mSv in the prior 12 months); 6. History of a bleeding disorder or are currently taking anticoagulants.

Study sites (1)

CT