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Neuroimaging of Parkinson's

Precision Neuroimaging of Parkinson's Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study uses MRI brain scans to learn whether a brain network called SCAN is changed in Parkinson's disease. It is for people with Parkinson's and healthy volunteers. The findings may help identify a target for future treatments.

Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • People in the Parkinson's group must have a doctor's diagnosis of Parkinson's disease.
  • People in the Parkinson's group must not have dementia, which causes serious problems with memory and thinking.
  • Healthy volunteers must have a normal brain and nerve exam, or only harmless findings.
  • Healthy volunteers must have normal memory and thinking skills.
  • Healthy volunteers must not have a parent, sibling, or child with Parkinson's disease.

Who can't join

  • Any brain or nerve condition other than Parkinson's disease.
  • A head injury that caused more than 5 minutes of being unconscious, or lasting brain or nerve problems.
  • Schizophrenia, bipolar disorder, or epilepsy (a seizure disorder).
  • Organ failure in its final stage, or current cancer treatment.
  • Dementia, or a score below 24 on the MMSE or below 21 on the MoCA. These tests check memory and thinking.
  • Metal implants or fear of small, closed spaces that prevents MRI scans.
  • Weight over 300 pounds, due to the MRI scanner's weight limit.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Must meet specific health and cognitive criteria depending on the group. For PD participants * Clinical diagnosis of Parkinson's Disease * Must not meet dementia criteria For Healthy Control Participants * Normal or benign neurological exam * Normal cognition * No first-degree relatives with Parkinson's Disease Exclusion Criteria: 1. Neurological Disorders (other than PD) \- Any other neurological condition 2. Significant Head Injury * Head injury with loss of consciousness \>5 minutes * Or any neurological sequelae 3. Psychiatric Disorders * Schizophrenia * Bipolar Disorder * Epilepsy 4. Serious Medical Conditions * End-stage organ failure * Ongoing cancer treatment 5. Cognitive Impairment * Diagnosis of dementia * MMSE score \<24 or MoCA score \<21 6. MRI contraindications * Metal implants * claustrophobia * Weight over 300 lbs (due to weight restrictions of the MRI scanner)

Study sites (1)

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