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Evaluation of the Natera Colorectal Cancer Screening Test in an Average Risk Population (FIND-CRC)

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Blood draws

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will provide blood samples and will be required to have a colonoscopy performed within 120 days of their blood draw."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

The FIND-CRC study checks how well the Natera screening test works for cancer of the colon or rectum. It collects blood samples and health data from adults age 40 or older who have an average risk of this cancer and plan to have a routine colonoscopy.

The FIND-CRC study is a prospective collection of samples and data from participants who are at average risk of developing colorectal cancer (CRC). Collected samples and data will be analyzed to evaluate the clinical performance of the Natera CRC Screening Test.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Sign a form agreeing to join the study.
  • Be age 40 or older when you sign the form.
  • Plan to have a routine colonoscopy, a test that uses a camera to look inside the colon and rectum.
  • Be able to have blood drawn with a needle.
  • Be able and willing to give blood samples within the 120 days before bowel cleaning and the colonoscopy.
  • Be able and willing to follow the study visit schedule and requirements.

Who can't join

  • Have ever had cancer. An exception is basal cell or squamous cell skin cancer removed by surgery at least 12 months before you agree to join.
  • Had a complete colonoscopy in the past 9 years, with the bowel cleaned well enough for the test.
  • Are having a colonoscopy to find the cause of symptoms.
  • Are up to date on colon and rectal cancer screening through a test that does not go inside the body.
  • Had changes that could turn into cancer found on your most recent colonoscopy.
  • Had surgery to remove part or all of the colon or rectum, unless it was for sigmoid diverticular disease—problems with small pouches in the lower colon.
  • Have inflammatory bowel disease, which causes long-term swelling in the digestive tract.
  • Have an inherited condition that raises the risk of colon or rectal cancer, such as Lynch syndrome.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Signed informed consent. 2. 40 years of age or older at the time of consent. 3. Planning or intending to undergo a standard of care colonoscopy. 4. Able to tolerate venipuncture for research draw(s). 5. Able and willing to provide blood samples within the 120 days prior to a standard-of-care pre-bowel preparation procedure and colonoscopy procedure. 6. Willing and able to comply with the study visit schedule and study requirements. Exclusion Criteria: 1. Any prior history of any kind of malignancy (exception: participants who have undergone surgical removal of skin squamous cell or basal cell cancers may be enrolled, provided the procedure was completed at least 12 months prior to consent for the study). 2. Had a complete colonoscopy with adequate bowel preparation in the previous nine (9) years. 3. Undergoing diagnostic colonoscopy for the investigation of symptoms. 4. Up to date with colorectal cancer screening from any non-invasive test. 5. Precancerous findings on most recent colonoscopy. 6. Had a prior colorectal resection for any reason other than sigmoid diverticular disease. 7. Known personal history of any of the following high-risk conditions: 7a. Inflammatory bowel disease. 7b. Known hereditary condition that would increase risk of colorectal cancer (example Lynch Syndrome).

Study sites (1)

TX