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A Music Therapy Study for Blood Cancer Survivors With Cognitive Difficulties

Pilot Trial of Telehealth Music Therapy for Cognitive Dysfunction in Hematologic Cancer Survivors (PRELUDE)

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether music therapy through online visits is practical for adult blood cancer survivors with thinking or memory problems. It also looks at whether music therapy and music education help with thinking, anxiety, depression, and tiredness.

Research has shown that music-based activities may help improve brain functions, such as attention, memory, and executive function. Because of this past research, the researchers are doing this study to find out whether telehealth music therapy is a practical treatment for cognitive difficulties in blood cancer survivors. The researchers will also study whether music therapy and music education help improve cognitive function and other common symptoms such as anxiety, depression, and/or tiredness.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are at least 18 years old and can understand and use English.
  • You have lymphoma, leukemia, or myeloma, which are types of blood cancer.
  • Your cancer is stable or there are no signs of cancer, based on your medical chart or cancer care team.
  • You score below 54 on the FACT-Cog PCI, a survey about thinking and memory problems.
  • Your clinician expects you to live at least one more year.
  • You can understand and complete all study tests and forms on your own.
  • You can understand the study consent form in English and sign it to agree to take part.

Who can't join

  • You finished surgery, radiation, initial chemotherapy for new or returned cancer, a transplant, or immune-based treatment less than 3 months ago. If treatment is ongoing, you must have completed at least 6 months. Maintenance treatment is allowed.
  • You had music therapy in the past year, are taking music lessons now, had more than 6 months of music training in the past 10 years, or plan to start training during the study.
  • You do not have a device that connects to the internet.
  • You currently have thoughts of suicide, bipolar disorder, schizophrenia, or substance abuse.
  • You score 10 or higher on the BOMC, a thinking and memory test. This score suggests dementia.
  • You have problems with seeing, hearing, or movement that cannot be corrected.
  • In the past month, you started or changed the dose of medicines that calm you, increase alertness, or block certain nerve signals. You also cannot plan to start these medicines during the study because they can affect thinking.
  • In the past month, you started another treatment for cancer-related thinking problems, such as training to improve thinking skills, or you plan to start one during the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * English-proficient, aged 18 or older * Diagnosis of lymphoma, leukemia, or myeloma * Stable oncologic disease or no evidence of disease as indicated in the medical chart or by the oncology team * Score of \<54 on the FACT-Cog PCI subscale * Minimum life expectancy of one year as per clinician assessment * Patient should be able to understand and complete all study assessments on their own. * Eligible patient should be able to understand informed consent and provide signed informed consent in English. Exclusion Criteria: * Less than 3 months since completion of surgery, radiation, induction chemotherapy (for newly diagnosed or relapsed disease), transplantation, or immunotherapy (e.g., CAR T-Cell, bispecific antibodies) * If there is a defined treatment period, the patient must be at least 3 months from treatment completion * If the patient is on continuous therapy, patient must have completed at least 6 months of the therapy * Maintenance therapies are allowed * Received music therapy (MT) in the past year * Current music training, \>6 months of music training in the past 10 years, or plan to initiate music training during the study * No access to an internet-connected device * Active suicidal ideation, bipolar, schizophrenia, or substance abuse * BOMC score ≥10 (indicative of dementia) * Uncorrectable visual, auditory, or motor impairments * Initiation or altered dose of sedative, stimulant, or anti-cholinergic medications in the past month or plan to initiate these medications during the study, as these are known to impact cognitive function * Initiation of any other interventions for CRCD (e.g., cognitive rehabilitation) in the past month or plan to initiate these interventions during the study, as these are known to impact cognitive function

Study sites (7)

NJ

NY