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Daily Amino Acid Supplementation for People With Parkinson's Disease

Effects of Targeted Amino Acid Supplementation for People With Parkinson's Disease on Amino Acid Profiles and Health Related Markers

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years to 90 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 6 months
  • Procedures mentioned: Blood draws

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will: Take the tailored amino acid supplement or a placebo every day for 6 months, visit the lab at baseline, after 3 months, and after 6 months for fasting blood draws, body composition assessment, and physical and mental health testing and keep a diary of their food intake and supplement intake."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a daily amino acid supplement helps nutrition, body makeup, and physical and mental health in adults ages 50–80 with Parkinson’s disease. Amino acids are building blocks of protein. Participants take the supplement or a placebo (a look-alike with no active ingredients) for 6 months and have lab visits and health tests.

The goal of this clinical trial is to learn if a tailored amino acid supplement works to help adults living with Parkinson's disease to improve nutrition, metabolic function, body composition, and physical and mental function. The main questions it aims to answer are: Does the tailored amino acid supplement increase essential amino acids (nutritional status)? Does the tailored amino acid supplement increase an antioxidant (complex amino acid) and decrease an amino acid associated with oxidative stress? Does the tailored amino acid supplement improve physical and mental health compared to a placebo supplement? Researchers will compare the tailored amino acid supplement to a placebo (a look-alike substance that contains no active ingredients) to see if the tailored amino acid supplements work to support health for people with Parkinson's disease. Participants will: Take the tailored amino acid supplement or a placebo every day for 6 months, visit the lab at baseline, after 3 months, and after 6 months for fasting blood draws, body composition assessment, and physical and mental health testing and keep a diary of their food intake and supplement intake.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Men and women ages 50–80.
  • Report a past diagnosis of idiopathic Parkinson’s disease, meaning the cause is unknown.
  • Have taken medicine that replaces dopamine, such as levodopa, for at least 2 years.
  • Have taken the same dose of that medicine for at least 3 months, with no plans to change it in the next 2 months.

Who can't join

  • Show thinking or memory problems on a phone screening test, with a score below 29.
  • Have Parkinsonism or atypical Parkinson’s disease, conditions that can look like Parkinson’s disease.
  • Are prescribed a medicine that blocks dopamine.
  • Have any medical condition that is not stable.
  • Use deep brain stimulation, a treatment that sends electrical signals to the brain.
  • Have had surgery to remove part or all of the stomach or bowel.
  • Have a medical reason that makes blood draws unsafe.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusionary Criteria: * Male and Females. * 50-80 Years. * Previous diagnosis of idiopathic Parkinson's Disease by patient report. * Use of dopamine replacement medication (e.g. levodopa) for at least 2 years. * On a stable dose of dopamine replacement medication for at least 3 months with no plans for change in the next two months. Exclusionary criteria * Apparent cognitive impairment as determined by phone screening (Telephone Interview for Cognitive Status \<29). * Diagnosis of Parkinsonism or atypical Parkinson's Disease. * Prescription of Dopamine antagonist. * Any unstable medical condition. * Use of Deep Brain Stimulation. * Gastric or Bowel resection surgery. * Contraindications to blood draw.

Study sites (2)

CT