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RecruitingPhase 4

Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department

Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department: A Randomized Control Trial

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study compares one shot of dexamethasone into a muscle with 5 days of prednisone to see how well they prevent a return to the emergency department (ED). Both are steroid medicines. The study is for adults treated in the ED for an asthma flare-up and then sent home.

This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are age 18 or older and come to the ED with an asthma flare-up.
  • You have asthma based on standard diagnosis rules or the treating clinician's diagnosis.
  • You are sent home from the ED with an asthma flare-up as your main diagnosis.
  • You start steroid medicine that works throughout your body during the ED visit.
  • You speak English or Spanish.

Who can't join

  • You already use steroid medicine that works throughout your body, including any given by emergency medical workers before you reach the ED.
  • You have had a severe bad reaction to steroid medicines.
  • You have heart failure and uncontrolled diabetes, with blood sugar above 300 mg/dL in the ED.
  • You are pregnant or breastfeeding.
  • You cannot give informed consent, meaning you cannot understand the study and agree to join.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Adults ≥18 years old presenting to the ED with an asthma exacerbation * Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician * Discharged from the ED with a primary diagnosis of asthma exacerbation * Initiated systemic corticosteroids during the ED visit * Must be English or Spanish speaking Exclusion Criteria: * Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival * History of severe adverse reactions to corticosteroids * Heart failure and uncontrolled diabetes (glucose \>300mg/dL in the ED) * Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population * Inability to provide informed consent

Study sites (1)

NY