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Potatoes, Type 2 Diabetes, and Cardiometabolic Health

Cardiometabolic Effects of a Potato-rich Diet in Older Adults at Increased Risk of Developing Type 2 Diabetes: A Randomized Controlled Feeding Study

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years to 70 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how eating whole white potatoes affects heart health and how the body handles blood sugar. It is for adults ages 50–70 who are at risk for type 2 diabetes but do not have diabetes.

Type 2 diabetes (T2D) is a major chronic health condition which increases risk of coronary artery disease, frailty, cognitive decline, and mortality. Additionally, hypertension is a major comorbidity for individuals with T2D, further increasing the risk of adverse cardiovascular outcomes. The prevalence of both conditions increases with advancing age. There is an urgent need to identify new approaches to prevent the development of T2D and improve cardiometabolic health in older adults 50-70 years of age. Whole white potatoes are an unprocessed food rich in essential nutrients often under-consumed by Americans, including potassium, fiber, magnesium, vitamins C and B6, and phytochemicals. Each of these nutrients individually are associated with cardiometabolic health benefits. Potatoes account for a significant amount of the intake of these nutrients in the US diet and are well-positioned to be a foundational element of a healthy dietary pattern. However, there are few interventional studies evaluating the effect of potatoes on cardiometabolic health, and the evidence from observational studies is mixed, leaving a significant gap in knowledge regarding the potential for potatoes to be included in healthy dietary patterns. The results of our proposed study will provide foundational data that inform future dietary guidelines regarding the inclusion of white potatoes as part of a healthy US dietary pattern.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 50–70 years old.
  • Your weight has changed by no more than 5% in the past 3 months.
  • You do little exercise or are active for fun.
  • You score at least 5 on the American Diabetes Association diabetes risk questionnaire.
  • You do not plan to change your weight or activity level.
  • You will pick up food daily and eat the study foods for 14 weeks.
  • You agree to join the study both out loud and in writing after learning about it.
  • If you use estrogen, testosterone, cholesterol-lowering drugs, blood pressure drugs, or thyroid replacement drugs, your dose has been stable for more than 6 months.

Who can't join

  • Your body mass index (BMI), a measure based on height and weight, is over 40.
  • You have diabetes, take diabetes or weight-loss drugs, or take drugs that affect how your body handles blood sugar.
  • You used antibiotics, prebiotics, or probiotics in the past 3 months. Prebiotics and probiotics affect bacteria in your gut.
  • Your total cholesterol is over 6.2 mmol/L, your triglycerides (a type of blood fat) are over 4.5 mmol/L, or your blood pressure is over 159/99 mmHg.
  • You have inflammatory bowel disease (long-term swelling in the gut), or have had heart disease, stroke, lung disease, hormone or metabolism disease, blood disease, or cancer.
  • You eat a vegetarian or vegan diet, or have allergies to or cannot eat the study foods.
  • You are pregnant or plan to become pregnant.
  • You have used estrogen, testosterone, cholesterol-lowering drugs, or blood pressure drugs for less than 6 months.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age 50-70 years * Weight stable for previous 3 months (±5% body weight) * Sedentary to recreationally active * ADA-Risk Screener questionnaire score of at least 5 * No plans to gain or lose weight or change physical activity level * Willing to pick up food daily and consume foods provided for a 14-week period * Verbal and written informed consent * Estrogen or testosterone use, lipid-lowering or blood pressure medication and thyroid replacement medication is acceptable, if on stable dose for \>6 months Exclusion Criteria: * Body mass index \>40 m2/kg * Diabetes or diabetes medication * Weight loss medication or medication influencing glucose metabolism * Antibiotic, prebiotic or probiotic use in prior 3 months * TCHOL \>6.2 mmol/L; TG \>4.5 mmol/L * Blood pressure (BP) \> 159/99 mmHg * Diagnosed inflammatory bowel disease * Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease * Vegetarian or vegan * Pregnant or plans to become pregnant * Food allergies or aversions to diet foods provided * Estrogen or testosterone usage, lipid-lowering medication, blood pressure medication usage \<6 months

Study sites (1)

VA