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Halt Aging in Survivors of Blood Cancers

Halt Aging in Survivors of Blood Cancers: the HALTAging-1 Study

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Mentioned in the study description

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Mentioned in the study description
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests exercise and ways to help people stick with exercise to see how they affect aging and health. It is for adults age 50 or older who have had blood cancer.

Older survivors of blood cancer are at a high risk of accelerated biological aging, which increases their risk of developing multiple aging-related conditions. Whereas physical exercise can improve overall health, older cancer survivors do not meet the recommended physical activity, highlighting the need to develop behavioral interventions to increase adherence. Several other knowledge gaps exist to implement exercise interventions in older survivors of blood cancer; the dose and duration of exercise necessary to slow biological aging in older blood cancer survivors remain unknown. To bridge these gaps in knowledge, we have designed a Phase 2 randomized control trial to test the effects of behavioral and exercise interventions on various outcomes.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are age 50 or older.
  • You have had blood cancer.
  • You can and are willing to give informed consent, meaning you understand the study and agree to join.

Who can't join

  • You are getting intensive chemotherapy to treat cancer or strengthen the treatment's effect. Ongoing maintenance treatment or milder chemotherapy for slow-growing blood cancer is allowed.
  • In the past 3 months, you have had a brain disease such as Alzheimer's, a stroke, or an uncontrolled mental illness such as schizophrenia or bipolar disorder that could keep you from taking part.
  • You have worsening heart failure, unstable chest pain, or bone, joint, nerve, or muscle problems that could make aerobic exercise unsafe.
  • Your heart and lung exercise test shows exercise may be unsafe, such as a dangerous heartbeat, balance problems, or very low oxygen use during exercise.
  • You are expected to live less than 6 months, which would prevent the study's main assessment.
  • You report being pregnant or possibly pregnant.
  • You do not plan to return to the study center for follow-up visits.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Age ≥50 years 2. A history of hematological malignancy 3. Participants must be able to and willingly give informed consent Exclusion Criteria: 1. Patients receiving intensive induction or consolidation chemotherapy. Maintenance chemotherapy, or lower-intensity chemotherapy for an indolent hematological malignancy is allowed. 2. Neurodegenerative disease (e.g. Alzheimer's dementia), stroke, or uncontrolled psychotic disorders (e.g. schizophrenia or bipolar disorder) in the past 3 months if those disorders are considered significant enough to impair participation in the study. 3. Illnesses such as clinical evidence of decompensated heart failure, unstable angina, or orthopedic or neuromuscular disorders that could limit safe participation in aerobic exercise. 4. Cardiopulmonary exercise test results that preclude safe exercise (e.g., life-threatening arrhythmia, balance difficulties, peak VO2 \<10 ml/kg/min). 5. Estimated life expectancy of less than 6 months (that precludes assessment of study primary endpoint). 6. Self-reported pregnancy or the possibility of pregnancy. 7. Participants who do not plan to follow up at the participating center.

Study sites (1)

NE