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Overcoming Barriers to Uptake of Cascade Screening

Let's Talk: Overcoming Barriers to Uptake of Cascade Screening Through a Stakeholder-informed Online Intervention

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Questionnaires, Interviews

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "After consenting to participate, they will be asked to complete a short pre-intervention survey and take part in a brief educational training to learn about the Let's Talk tool."
  • "Once each patient enrolls, they will complete a short pre-intervention survey and then will be introduced to the online Let's Talk toolkit."
  • "Two months following the delivery of Let's Talk, patients will be given a brief online survey and a qualitative interview to assess outcomes (n=15)."
  • "Post-intervention surveys and interviews will also be conducted with genetic counselors at the end of the study (n=5)."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether an online tool called Let's Talk can be used in clinics to help people with Lynch syndrome encourage blood relatives to get genetic testing. Lynch syndrome is an inherited condition that raises cancer risk. The study is for adults with Lynch syndrome and genetic counselors.

Lynch syndrome is a genetic condition that increases cancer risk. The public health impact of genetic testing for disease prevention hinges on cascade screening, which is the systematic identification and testing of blood relatives after a family member has been diagnosed with a genetic condition. Despite its importance in disease prevention, only half of first-degree relatives of individuals with Lynch syndrome undergo cascade screening. To address this gap, the study will pilot test an online version of Let's Talk, a novel intervention designed to support and promote cascade screening. This intervention tool is designed to support and encourage more family members to get screened. The purpose of this study aim is to assess the feasibility of the online Let's Talk tool in clinical use by examining implementation and effectiveness outcomes related to the use of the planning tool across three clinics at a large academic-affiliated medical center with patients (n=15) seen by one of five genetic counselors (n=5).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • All participants must be age 18 or older.
  • All participants must give written consent to join the study.
  • All participants must be willing and able to follow study steps, as judged by the study team.
  • Patients must report that they have been diagnosed with Lynch syndrome.
  • Genetic counselors must report that they work as a practicing genetic counselor at a medical institution. These counselors help people understand inherited health risks.

Who can't join

  • Patients cannot join if they have already told all relatives about their Lynch syndrome diagnosis.
  • Genetic counselors cannot join if they are not employed.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria for Patients * Written informed consent obtained to participate in the study. * Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee. * Age ≥ 18 years at the time of consent. * Written informed consent obtained to participate in the study. * Self-reported Lynch syndrome diagnosis. Inclusion Criteria for Genetic Counselor * Written informed consent obtained to participate in the study. * Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee. * Age ≥ 18 years at the time of consent. * Written informed consent obtained to participate in the study. * Self-reported employment as a practicing genetic counselor at a medical institution. Exclusion Criteria for Patients * The patient has already notified all relatives about their diagnosis with Lynch syndrome. Exclusion Criteria for Genetic Counselor * Genetic Counselor is not employed.

Study sites (1)

NC