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Electrophysiology-based DBS Programming for PD

Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
21 Years to 89 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether brain signals can help choose settings for deep brain stimulation (DBS), a treatment for movement symptoms in Parkinson’s disease. It compares two ways of using brain signals with settings chosen by a clinician. It is for adults ages 21 to 89 with Parkinson’s disease who have a Percept DBS device.

Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have Parkinson’s disease with no known cause, diagnosed using Movement Disorder Society guidelines.
  • Have a Medtronic Percept DBS device implanted to treat movement symptoms.
  • Be able to understand the study and agree to take part.
  • Be willing to join the study at the first session to set up the device.
  • Be 21 to 89 years old.

Who can't join

  • Cannot follow the study requirements.
  • Have atypical parkinsonism, a condition similar to but different from typical Parkinson’s disease.
  • Have personality or mood symptoms that study staff believe would make it hard to meet study requirements.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Patients with a diagnosis of idiopathic PD fulfilling the Movement Disorder Society Clinical Diagnostic Criteria for PD * DBS implantation with the Percept DBS device (Medtronic, USA) for the treatment of motor symptoms * Ability to give informed consent for the study * Willingness to do this study at the time of the initial programming session * Age 21 to 89 years old Exclusion Criteria: * Inability to comply with the study protocol * Atypical Parkinsonism * Any personality or mood symptoms that study personnel believe will interfere with the study requirements

Study sites (1)

FL